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Table of Content

    18 October 2016, Volume 33 Issue 5 Previous Issue    Next Issue
    Composition and diversity of small mammals community in Shilong, Jianchuan area of Yunnan Province
    ZHU Wan-long, ZHANG Hao, MENG Li-hua, CAI Jin-hong, WANG Zheng-kun
    2016, 33 (5):  1. 
    Abstract ( 336 )   PDF   Save
    Community composition and diversity of small mammals from Jianchuan Shilong region in Yunnan Province were studied in the present study. The results showed the total distribution of small mammals in Shilong area including 23 species, belonging to 4 orders, 7 families. A total of 13 years of cloth cage 17 1482, a total of 15 338 small mammals were captured, with the capture rate of 8.94%. Of which Apodemus chevrieri was 7009, Eothenomys miletus was 6471, which accounted for 87.89% of the total mammals, remaining 21 captured animal species accounted for only 12.11%. Changes of number in E. miletus and A. chevrieri showed no significant difference among different years, but had significant differences among months, the capture rates of the two rodents were higher in the concentrated in summer. The number of small mammals showed significant differences in four small mammal habitats, which were lower in indoor neighborhood region, and higher in the shrub. These results indicated of that small mammals in Shilong area were rich in diversity, and the number of rodents was closely related to the breeding season.
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    Changes of egg envelope of sweet fish Plecoglossus altivelis during post-ovulatory ageing
    XU Yu-min, MIAO Liang, LI Ming-yun, AN Qin, LI Xiao-meng,MU Fang-shen, HOU Hong-hong, CHEN Jiong
    2016, 33 (5):  5. 
    Abstract ( 293 )   PDF   Save

    The mature oocytes of sweet fish Plecoglossus altivelis can maintain fertilization ability for a long time. In this study, we observed the ultrastructure′ changes of P. altivelis oocytes during post-ovulatory process using transmission electron microscope(TEM). In follicular phase, the outer layer of oocyte memebrane is zona radiate(ZR), which includes three-layers(ZR1, ZR2 and ZR3 from outside to inside, and the thickest layer is ZR1). Outside of ZR is jelly coat(JC). After ovulation, ZR1 disappears and ZR remains two layers (ZR2 and ZR3), and JC still exisst. In this stage, ZR2 is very thin, and ZR3 includes 5 light-bands alternate with 5 dark-bands. ZR3 is completely opaque, and in the vertical of oolemma showed alternating "light region" and "dark region". At 48 h after ovulation, JC disappears, ZR is thinner and pore canals(PC) appears in ZR3. At 60 h, the number of PC increases and diameter enlarges. To 96 h, the length of PC increases to 1/2 of the ZR3. 104 h later, with the disintegration of ZR2, PC continues to elongate and pass through ZR3, and then the mature oocyte completely apoptosis.

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    The comparison between two states of Oujiang color common carp,Cyprinus carpio var. color scales
    XU Hui-bin, ZHANG Qian, WANG Cheng-hui, GONG Xiao-ling
    2016, 33 (5):  8. 
    Abstract ( 276 )   PDF   Save
    Two obvious conditions exist in the scales of Oujiang color carp, Cyprinus carpio var. color. Form one is hard,transparentinsert skin section,smooth back region (named form A)and form two is soft,notsmoothinsert skin section,fold back region (named form B). We analyzed of two types of scales of the same size, the same age and the same parts . The SEM result showed that theformBscalesshowedmore chaotic permutation, and the distances between two scale ridges showed F>F0.01(1,268)=54.095,(P<0.01). The paraffin sections result showed that thethickness of form A scales (109.53±3.74)μm is more thick than the soft scales (55.450±7.40)μm, and the fiber layer of hard scales showed layered distribution,and the bone layer of hard is thicker. The DigiEye result showed that the color is different soft scales and hard scales. There were significant differences between soft scales and hard scales,and these may lead to differences between form A scales and form B scales. On the basis of the previous research results: A, B two types scales morphology, biochemical composition and color in the presence of significant differences, which may resulted in the Oujiang color common carp scales hardness, transparency and color of different.
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    Study on the selectivity of Carassius auratus under different environment colors and luminous intensities
    GONG Jian-hua, GUO Chun-yang, TIAN Zhe, XU Shan-liang
    2016, 33 (5):  13. 
    Abstract ( 392 )   PDF   Save
    The selectivity of Carassius auratus under six kinds of colors (black, blue, red, green, orange and yellow) and different illumination intensities was sudied. The results indicated that there were extremely significant differences(P<0.01) among six colors trend to be selected by Carassius auratus. Distribution law(F) and selection index(E) indicated that the fish preferred black first, followed by blue, red, green, orange and yellow. Distributions in the fish tank were uneven, which meant they preferred to the right and left side than the center. When the light intensity was only 23 lx at night, the preference ranking to the colors was consistent with the result in the daylight. As above, Carassius auratus had positive phototactic response, and it was one kind of strong-light deflection fish of which the phototactic threshold value was about 1400 lx.
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    Distribution features and risk assessment of OCPs in muscle parts of five fishes from Chao Lake
    XU Biao, SUN Bing-hua, JIANG Shan, WU Huan-ling, LI Jin-hua
    2016, 33 (5):  19. 
    Abstract ( 266 )   PDF   Save
    In order to understand the tissue accumulation of OCPs in five different diet fishes of Chao Lake, and to probe into the rationality of back muscle sampling method and the organochlorine pesticide risk of Chao Lake, we analyzed the concentrations of HCHs and DDTs in four muscle parts of five fish species from Chao Lake by the following methods of soxhlet extraction, sulfonate degrease, chromatographic column purification, rotary evaporation, nitrogen blow concentration, and analysis by GC/MS. Results showed that the average concentration of OCPs was from 2.929 ng/g to 10.523 ng/g. Specifically, concentrations in different fishes were listed as below: catfish (10.523 ng/g) > chub (6.407 ng/g) > snakeheaded fish (4.514 ng/g) > black carp (3.390 ng/g) > crucian (2.292 ng/g).OCPs in upper tail muscles (from catfish and snakeheaded fish) and belly muscles (from chub and black carp) were both significantly higher than those in back muscles. It was estimated that daily concentrations of HCHs and DDTs from species fish Chao Lake was far lower than daily food intake from national standard. In conclusion, concentrations of OCPs in typical fishes of Chao Lake appeared that carnivore fishes > phytophagous fishes > polyphagia fishes. The accumulation of OCPs in back muscle was just one of the features of OCPs in entire fish muscles.
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    Effects of salinity on the growth and survival rates of juvenile Mercenaria mercenaria (Linnaeus, 1758)
    ZHOU Hai-bo,XU Ji-lin, RAN Zhao-shou
    2016, 33 (5):  23. 
    Abstract ( 301 )   PDF   Save
    The effects of salinity on the growth and survival of juvenile Mercenaria mercenaria of two different sizes were studied by employing indoor culture method. The results showed that the most suitable growth and survival salinity was about 27.8 for juveniles of two different sizes. Juveniles would die within 48 h when the salinity was lower than 14.4. The survival rate (SR) and growth rate (GR) of juveniles increased along with the salinity from 14.4 to 27.8, but decreased when the salinity increased from 27.8 to 35.9. There was stronger resistance to salinity for the juvenile M. mercenaria of larger sizes when compared with the smaller ones. In conclusion, artificial culture of the juvenile M. mercenaria is more suitable in the south coast of China, and adult culture is more suitable in the north coast areas.
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    Immunomodulatory effects of melanin from Sepiella Maindroni ink on hypoimmune mice
    DONG Hui, WANG Li-dong, WANG Chun-lin, SONG Wei-wei, MU Chang-kao, LI Rong-hua
    2016, 33 (5):  27. 
    Abstract ( 247 )   PDF   Save
    In this study, the immunomodulatory effects of MSMI (melanin from Sepiella maindroni ink) on hypoimmune mice induced by Hydrocortisone(HYD) was investigated . ICR mice were selected as animal mode, which were randomly divided into six groups, including control groups, hypoimmune mice, positive control groups(Levamisole Hydrochloride), and MSMI treated groups of low, medium and high dosage. Except for the control group, all the other groups were treated with Hydrocortisone by subcutaneous injection. After a trial period of 10 days, the liver and spleen indexes and phagocytic capacity of macrophages were analyzed, and which were found to be significantly enhanced in the treated groups(P<0.01,P<0.01),(P<0.05,P<0.01) as compared to that in the control group. Antioxidant enzyme activities were also measured and they significantly increased compared to the hypoimmune mice group. However, lipid peroxidation assayed as melondialdehyde (MDA) reduced significantly in the treated groups compared to that in the control. It is suggested that MSMI can promote immune function of immune-depressed mice.
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    Callus induction and proliferation of citrus huanglongbing host plant Catharathus roseus (L.) G. Don
    SONG Xiao-bing,PENG Ai-tian,CHEN Xia,LING Jin-feng,ZHANG Lian-hui
    2016, 33 (5):  31. 
    Abstract ( 270 )   PDF   Save
    In this study, the tissue culture system of Catharathus roseus (L.) G. was presented. Using the young leaves of C. roseus (L.) G. as explants, the callus induction and proliferation system of C. roseus (L.) G. was explored through screening disinfection treatment of explants and different hormone formulation. The results showed the explants sterilization treatment combination was 75% ethanol for 30-45 s and 0.1% mercuric chloride for 3 min. The medium was MS, the hormones combination were 2,4-D 1.0 mg/L-1+NAA 1.0 mg/L-1+6-BA 2.0 mg L-1 for the callus induction, and the hormones combination were NAA 1.0 mg L-1+6-BA 2.0 mg L-1 for callus proliferation. The results showed that the callus induced ratio of C. roseus (L.) G was higher than 90%. The culture system of callus induction and proliferation was established, which will be important for the resistance breeding using transgenic engineering technology to control citrus huanglongbing disease.
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    Commuinity dynamics of phytoplankton and related affecting factors in Shengjin Lake
    WU Fang-yi, WANG Lan, XU Mei, WANG Hui, ZHOU Zhong-ze
    2016, 33 (5):  34. 
    Abstract ( 400 )   PDF   Save
    Seasonal and spatial variations of phytoplankton communities and its relationships with the main environmental factors in Shengjin Lake in February, April, July and November of 2014 were investigated. The results showed that in total of 210 species of phytoplankton were identified, which belonged to 91 genera of 8 phyla.Chlorophyta were most abundant,with 36 species of 89 genera(41.20%),and Bacillariophyta were the second,with 62 species of 26 genera(28.70%).The highest biomass recorded in summer(21.17±3.62 mg/L on average) and lowest recorded in winter(0.42±0.11 mg/L on average), the highest density was(4.57±0.29)×108cells/L in summer and lowest was(3.66±4.03)×105cells/L in winter. The seasonal succession of phytoplankton was consistent with PEG model in Shengjin Lake.Community structure analysis showed that Bacillariophyta was the second dominant population after Chlrophyta.The Shannon-Wiener index indicated phytoplankton diversity of 2.56-8.05(average 5.21). Redundancy analysis(RDA)revealed that the biomass of dominant functional was positively correlated with T,pH and SD.
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    Vascular plant community types and flora in Shengjin Lake National Nature Reserve
    LIU Jing-jing, ZHOU Zhong-ze, TIAN Huan-xin, WAN Yang, ZHAO Li-na
    2016, 33 (5):  40. 
    Abstract ( 315 )   PDF   Save
    The survey on the vascular plants in Shengjin Lake National Nature Reserve was done form August 2014 to June 2015. The community types were divided in to 6 vegetation types, 12 vegetation subtypes and 32 formations. The main community types were Ass. Pinus massoniana, Ass. Cyclobalanopsis glauca, Ass. Quercus acutissima + Liquidambar formosana, Ass.Ilex cornuta, Ass. Lindera glauca, Ass.Zizania caduciflora, Ass. Carex thunbergii, Ass. Trapa maximowiczii, and so on. Ass.Carex thunbergii was the advantage association of coastal tidal flats, the number, height, coverage, biomass of Carex thunbergii in different water depth were obviously different. Through analyzing the correlation between number, height, coverage, biomass of Carex thunbergii change with depth, it showed that the coverage and the biomass were highly significant correlation with the depth (P<0.001) and the number was significant correlation with the depth (P<0.05), but the height was not significant correlation with depth (P>0.05). There were 510 vascular plant species belonging to 335 genera in 125 families. 125 families were divided into 14 distribution types, and 335 genera were divided into 22 distribution types. The main distribution types were Cosmopolitan, Pantropic and North Temperate. 
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    Identification of CRY1-interactive transcription factor proteins
    HE Zhi-min, FENG Pan-pan, RONG Duo-yan, ZHAO Xiao-ying, LIU Xuan-ming
    2016, 33 (5):  47. 
    Abstract ( 371 )   PDF   Save
    Arabidopsis CRY1 (cryptochrome 1) protein initiates blue light signal transduction in a protein interaction manner, consequently causes the photomorphogenesis in plants. To further study the mechanism of CRY1 mediating blue light signal transduction, CRY1 was used as a bait, the methods of yeast two hybrid system, such as preliminary auxotrophy, liquid assays and domain interactions analyses in yeast cells were employed to screen the transcription factor proteins from the Arabidopsis transcription factor yeast library. The results showed that 41 transcription factor proteins were screened out by the preliminary auxotrophy and the liquid assays with ONPG as substrate; the transcription factor proteins which interacted with CRY1 with high blue light dependent or strong enzyme activity were picked out for a further validation using liquid assay with CPRG as substrate, and found that their interactions with CRY1 showed blue light dependent and the activity of interactions would increase with the time of blue light treatment; the interactions analyses results of CRY1 domains and transcription factor protein showed that the transcription factor proteins SPL3 and IDD4 interacted with the N terminus of CRY1 primarily, and relatively weak with the C terminus, however, the blue light dependent existed between the interaction of the C terminus of CRY1 and SPL3, but not so obvious with IDD4
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    Gene cDNA cloning and expression analysis of stat6 from Lateolabrax japonicas
    YU Xiao-na, LIU Yan-jie, QIAN Yun-xia
    2016, 33 (5):  53. 
    Abstract ( 235 )   PDF   Save
    Signal transduction and transcriptional activation factor 6 plays an important role in the inflammation induced by IL-4 and IL-13. A full-length cDNA of the stat6 in sea perch (Lateolabrax japonicus) was amplified by RT-PCR and SMART RACE methods. The cDNA was 3938 bp with 5′-UTR of 295 bp, 3′-UTR of 1369 bp and open reading frame of 2274 bp. It encoded a protein of 757 amino acids with the molecular weight of 86.43 ku and pI 5.90. The blast analysis indicated that the deduced amino acids sequence of sea perch STAT6 shared the highest identity of 93.7% with Siniperca chuatsi and the lowest identity of 41.7% with homo sapien. Real-time PCR results showed that stat6 was expressed in all tissues tested with higher levels in spleen, kidney, brain,intestine and gill. The expression of stat6 increased obviously in spleen, kidney, intestine and gill after intraperitoneal injectin of Vibrio harveyi. This obtained information will provide a theoretical basis for studying the molecular mechanism of fish stat6 in regulating fish immune response to pathogens.
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    Construction of adenovirus vector containing adipsin and  its therapy on 2 type diabetes rat model
    ZHANG Lei, ZHOU Yan, YAN Shan-shan, XIE Yu-ping, GENG Pan-pan,SUN Mao-sheng, LI Hong-jun
    2016, 33 (5):  58. 
    Abstract ( 293 )   PDF   Save

    Adipsin is one of the most abundant and specifically expressed adipose proteins and plays pivotal roles in energy homeostasis and systemic metabolism as a circulating factor linking fat cells and obesity to β cell function. To evaluate whether treatment with adipsin could prevent the metabolic abnormalities associated with diabetes and obesity, we examined the effects of overexpression of adenoviral-mediated adipsin (Ad-adipsin) in hyperlipidemic type 2 diabetic rats. Type 2 diabetic rats (n=5) were administered intravenously with Ad-adipsin. Overexpression of adipsin significantly reduced serum resistin, fasting blood glucose (FPG) levels, fasting insulin value(FINS), total serum cholest(TC), triglyceride(TG), and low density lipoprotein(LDL) on the 7th day after treatment (P<0.05). In addition, glucose tolerance and insulin sensitivity were markedly increased (P<0.05). These results indicated that the treatment with Ad-adipsin improves glucose and fat metabolism in type 2 diabetic rats.

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    Establishment and evaluation of glycation model induced by D-galactose in mice
    JI Xiong-fei, WANG Li-dong, WANG Chun-lin, SONG Wei-wei, MU Chang-kao, LI Rong-hua
    2016, 33 (5):  63. 
    Abstract ( 289 )   PDF   Save

    To provide a theoretical basis of a new rat model of glycation, the mice of glycation were induced by injecting D-galactose (200 mg kg-1 d-1) using injecting method for 45 days, which were measured the behavioral differences from model group to others and detected the index related to the glycation as AGEs, RAGE, sRAGE and esRAGE in variety organs of mice ( as brain, heart, liver, spleen, lung, kidney, skin, muscles and serum). The results showed that the DI of model group was decreased compared with that of the control group (P<0.01), though the number value of AGEs, RAGE, sRAGE and esRAGE of each tissues in mice were higher than that of control (P<0.01). This experiment investigated that it could make organism in a state of high glycosylation when they were injected by D-galactose (200 mg kg-1 d-1) for 45 days. The model could be used in the study of the etiopathogenesis of AGEs which could discover the receptors and the pathway of pharmaceutical drug. And the index changing form in multiple tissues would give the researchers some suggestions in experimental targets using the model.

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    The inhibitory effect of resveratrol in hepatocellular carcinoma Smmc-7721 cells
    LI Lu, WANG Lu, CHEN Guang-liang, HUANG Mei-xian, SONG Rui, WEI Qiang
    2016, 33 (5):  67. 
    Abstract ( 334 )   PDF   Save
    To investigate the inhibitory effect and mechanism of resveratrol in hepatocellular carcinoma cells, cell viabilities were detected by MTT assay and protein levels were detected by Western blotting. The results indicated that resveratrol significantly exhibited inhibitory effect in hepatocellular carcinoma Smmc-7721 cells. And the level of p-Erk1/2/Erk1/2 significantly decreased in cells treated with resveratrol. Furthermore, the level of p-mTOR/mTOR significantly increased in cells treated with resveratrol. But, there was no significant change in the level of p-Akt/Akt. The data suggest that resveratrol exhibits the inhibitory effect via Erk1/2 pathway in hepatocellular carcinoma cells. And resveratrol can regulate the energy metabolism via mTOR pathway in hepatocellular carcinoma cells.
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    Study on oral bio-availability of collagen peptides
    LIU Dong-yan, YIN Li-duan, QIN Song,YU Jian-wei,YAN Ming-yan,SHI Li-hua
    2016, 33 (5):  71. 
    Abstract ( 244 )   PDF   Save
    This study researched different molecular weight peptides on oral bio-availability. On the basis of smaller molecular weight with easier absorbed, three molecular weight peptides(<1 ku,1-3 ku,3-6 ku) were experimented on rat,then chose a collagen peptides with high oral bio-availability by determining the hydroxyproline content of feces, urine, and blood. The result showed that 1-3 ku cod skin collagen peptides exhibits higher oral bio-availability. This research would provide a base for health care production.
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    Study on adsorption property of Cr6+ by sycamore bark activated carbon
    WANG Lei,WEI Xin-lai,JIN Jie,LI Cong,WANG Pei-yang
    2016, 33 (5):  75. 
    Abstract ( 292 )   PDF   Save
    The adsorption property of Cr6+ by sycamore bark activated carbon was studied. The related thermodynamic parameters were obtained. The research results showed that using 0.4 g sycamore bark activated carbon for the treatment of 50 mL Cr6+ solution concentration of 100 mg/L, under the condition of temperature, pH and adsorption time of 25℃, 2.0 and 180 min, the removal rate of Cr6+ reached to 99.8%. Sycamore bark activated carbon adsorption of Cr6+ conformed to the Langmuir model, and it the saturated adsorption capacity was 7.888 mg/g when the temperature was 10℃.
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    Advance in molecular mechanism of autophagy induced by cadmium
    SHI Mei-lin, ZHOU Yang, LIU Hai-tao, XU Rong-fa, SHI Hai-feng
    2016, 33 (5):  79. 
    Abstract ( 419 )   PDF   Save
    Cadmium is a common environmental pollutant, which causes cell apoptosis. Recently, some researches have shown low levels of cadmium exposure could cause cell autophagy. Autophagy, an evolutionarily conserved mechanism for sequestering and degrading long-lived cellular proteins and damaged organelles, is important in normal development and serve as a response to changing environmental stimuli. Its alteration is associated with many physiological and pathological process of the body, such as neurodegenerative diseases, cancer, pathogenic microorganism infection. The molecular mechanism of autophagy induced by cadmium is involved in many signal pathways, which can be induced by the generation of reactive oxygen species(ROS) and to activate liver kinase B1-AMP-activated protein kinase (LKB1-AMPK) signaling pathway, or a rapid elevation in cytosolic calcium to activate calmodulin-dependent protein kinase. Autophagy can also be induced by ER stress. Numerous studies show that autophagy induced by cadmium plays an important role in cell death, while other studies indicate that autophagy can serve as a protective mechanism against cadmium caused cell death. Although the cadmium induced autophagy has been investigated intensively, the underlying mechanisms are not yet completely understood. The purpose of this review was to elaborate the molecular mechanism of autophagy induced by cadmium.
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    Comparison between respiration and fermentation of chemoheterotrophic microorganisms
    FENG Fen, YANG Tian-ran, CHEN Ping, XIN Ming-xiu
    2016, 33 (5):  83. 
    Abstract ( 529 )   PDF   Save

    Chemoheterotrophic microorganisms obtain energy by respiration or fermentation. However, respiration or fermentation, especially anaerobic respiration and fermentation are usually misused in many situations. The concepts, characteristics and utilization of aerobic respiration, anaerobic respiration and fermentation were compared. The relationship and difference between them were also analyzed in this paper.

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    The structure, mechanism and application of clustered regularly interspaced short palindromic repeats system
    CHEN Jin, WANG Su-ying, DONG Shi-rui
    2016, 33 (5):  87. 
    Abstract ( 301 )   PDF   Save
    tClustered regularly interspaced short palindromic repeats (CRISPR) is a kind of repetitive DNA structure, which is widely distributed in bacterial and archaeal genomes. The structure with leader sequence and a series of associated proteins together provide acquired immunity against phage and plasmid genes for prokaryotes. In this paper, the structure, mechanism and application of CRISPR system are summarized, the latest research progress is introduced, and the prospect of its development is prospected.
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    Research progress in relationship between AKR7A and disease
    ZHANG Ming-gang,YANG Jun
    2016, 33 (5):  90. 
    Abstract ( 371 )   PDF   Save
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    Advances in tissue culture and genetic transformation of pea
    ZHANG Li-juan,YANG Xiao-ming, WANG Chang, LU Jian-ying, MIN Geng-mei
    2016, 33 (5):  94. 
    Abstract ( 372 )   PDF   Save
    This paper reviewed new development on tissue culture and genetic transformation of pea at home and abroad in recent years. It described research achievements on genotypes, explants, basic medium, exogenous hormones in the process of tissue culture, etc, and summarized emphasisly the effects of different types, concentration and combinations of hormone on callus induction, root and buds differentiation in pea. At the same time, the paper summarized research progress on genetic transformation of pea, and finally discussed and prospected the main problems and future research directions of genetic transformation in pea.
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    Research progress on biological waste improving saline-alkali land
    WANG Zhi-yong, SHI Chun-fang, LENG Xiao-yun, LIU Ju-mei, CAO Ju-mei
    2016, 33 (5):  100. 
    Abstract ( 259 )   PDF   Save
    Saline soil is a special type of a class of land resources, and the improvement of saline soil has double benefit to the protection of the ecological environment and the development of rural economy. Saline soil can be improved by using all kinds biological waste. In these biological waste,the content of organic matter and nutrients N/P/K was very rich. When using this improvement method, the costs were lower and the improvement effect was ensured. Straw, biogas residue, biogas, sludge and other biological waste can be applied in the saline soil improvement. This paper mainly summarized research progress on saline soil improvement of using these three types of biological waste.
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    Applied study on aflatoxin B1 toxicity of the feed degraded by Pleurotus Ostreatus concentrated fermentation
    HU Chang-ying, YANG He-bao, LUO Tong-yang, WANG Yun-peng
    2016, 33 (5):  103. 
    Abstract ( 249 )   PDF   Save
    null
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    Mutation breeding of doramectin mutant strain and study on fermentation
    ZHU Wan-yi, REN Min, WANG Dong-mei, ZHU Peng-fei, ZHAI Zhi-hua, LIN Qing-ping,ZHANG Rui, ZHU Jie, CHEN Ying-ying, LI Hui-juan, LING Qing-yun
    2016, 33 (5):  106. 
    Abstract ( 353 )   PDF   Save
    The mutant strain 1692#was obtained from an original strain Streptomyces arermitilis 13#using strain mutation screening method. Within the optimizing of the fermentation medium composition and the fermentation process, the production of the mutant strain was 127% higher than that of the original one. The mutant strain and the optimized fermentation process would provided a reference for the industrialized production of doramectin.
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    The application of excel in simulating genetic drift
    DING Jian-hua, ZHANG Hai-jun
    2016, 33 (5):  109. 
    Abstract ( 501 )   PDF   Save
    Genetic drift is a fluctuation phenomenon of gene frequency due to the random error caused by sampling in small population. Whether in nature or in the domestic conditions, the genetic drift phenomena are common. Therefore, it has received much attention in the teaching of genetics. The concept of genetic drift is important in explaining some evolutionary phenomena, as well as breeding work, the establishment of gene pool and so on. In order to better display the genetic drift rule, Excel 2003 is used to simulate the process of drift, and it is expected to understand the drift direction and the degree more vivid and profound.
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    Teaching practice of molecular biology in a mode of scientific story-directed
    Morigen, XING Wan-jin, FAN Li-fei, Hada, Hasi Agula
    2016, 33 (5):  112. 
    Abstract ( 284 )   PDF   Save
    Using "the central dogma" as a main stream, five domains of structure and function of DNA, RNA and protein, DNA replication, damage repair and transposition, transcription control, translation regulation, synthetic biology and molecular operation are designed for teaching of molecular biology. A scientific-story-directed teaching mode where the theories can be discussed through telling stories behind the discoveries has been practiced. The story-directed teaching mode is found to be good for students to learn the biological theories and methods in an interesting and easy way, to understand the logic and reasoning behind the theories as well.
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    Practice and thinking of teaching innovation reform in mycology course
    LI Zhi-dong, WU Xing-an, XU Zhi-kai
    2016, 33 (5):  117. 
    Abstract ( 262 )   PDF   Save
    According to the requirements of talents training target, mycology course in biotechnology major involves the integration of three elements, that is biotechnology, medicine, and military. In the teaching process, we promote omni-directional innovation reform, such as the compilation and application of new textbook, the innovation of preparation meeting before class, the reform of test and marking, etc, to improve the quality of teaching, as well, to make the students master the basic knowledge, basic methods and basic skills. At the same time, we try to train the students to solve the problems in production and living, in medical practice and military training.
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    The application of digital education resource in pathogenic biology experimental teaching
    YANG Shu-feng, DENG Guo-ying, LIU Xin, SUN Wen-chang
    2016, 33 (5):  120. 
    Abstract ( 216 )   PDF   Save
    The effective application of digital education resource in pathogenic biology experimental teaching can inspire the students′ learning interests and improve the ability to resolve difficulty. This article will discuss the application of digital education resource in pathogenic biology experimental teaching, according to experimental platform building, digital resource developing, multiple teaching methods using and experimental assessing.
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    Exploration of teaching and test reform in general zoology for biological major
    WANG Lei, ZHAN Yong-le, LIU Chao-liang
    2016, 33 (5):  123. 
    Abstract ( 290 )   PDF   Save
     General zoology is a wide range of basic subjects, and it has important role in professional education for biological major. In order to adapt to the cultivation needs for biological major, authors attempted to do some reforms including teaching content, teaching methods, practical teaching and test mode in general zoology teaching, to promote the innovation abilities of students.
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    The application of the research-oriented teaching pattern in the microbiological experimental teaching based on theme design
    ZHANG Hong-yu, WANG Su-ying, YANG Xiao-li
    2016, 33 (5):  125. 
    Abstract ( 216 )   PDF   Save
    The traditional teaching is a process that the teachers acts as the center to instill in the knowledge to students, which is a closed system of knowledge transfer. In this paper, the positive significance of open research-oriented teaching mode on the microbiological experimental teaching was discussed, it not only inspire the enthusiasm of students to learn microbiology, but also expand students′ knowledge structure and develop students′ innovative consciousness, innovative thinking and innovative ability. This will lay a foundation for training the students to be high quality practical talents with deep foundation and strong abilities.
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