Abstract: To investigate the inhibitory effect and mechanism of resveratrol in hepatocellular carcinoma cells, cell viabilities were detected by MTT assay and protein levels were detected by Western blotting. The results indicated that resveratrol significantly exhibited inhibitory effect in hepatocellular carcinoma Smmc-7721 cells. And the level of p-Erk1/2/Erk1/2 significantly decreased in cells treated with resveratrol. Furthermore, the level of p-mTOR/mTOR significantly increased in cells treated with resveratrol. But, there was no significant change in the level of p-Akt/Akt. The data suggest that resveratrol exhibits the inhibitory effect via Erk1/2 pathway in hepatocellular carcinoma cells. And resveratrol can regulate the energy metabolism via mTOR pathway in hepatocellular carcinoma cells.

Key words: liver neoplasms, resveratrol, p-Erk1/2/Erk1/2； p-mTOR/mTOR； p-Akt/Akt； energy metabolism