Study on the blood compatibility of biomimetic polymer film mimicking the locust wing
2021, 38 (5):
Using locust wing as template and polydimethylsiloxane (PDMS) as substrate, biomimetic polymer films were prepared by means of soft etching and dual transcription, and the blood compatibility of the biomimetic film surface was evaluated. Based on the results, the micro-morphology of wing surface was replicated successfully on the biomimetic film, which exhibited high resistance against water (contact angle 141.3°-147.6°) and blood (contact angle 119.8°-126.3°) as well as fine blood compatibility. On the surface of biomimetic film mimicking the wing of Oxya chinensis, Chondracris rosea rosea and Locusta migratoria manilensis, the amount of platele adhesion were 3.06×104, 2.83×104 and 0.95×104 ind./cm2, respectively, remarkably lower than that (10.89×104 ind./cm2) on the CK film. On the surface of biomimetic film mimicking the wing of L. migratoria manilensis, the amount of platele adhesion was the lowest, just 8.7% of the CK; meanwhile, the platele kept intact form, was not activated, without pseudopodia, deformation, and aggregation, implying better anticoagulant function and longer dynamic coagulation time. On the surface of biomimetic film, the hemolysis rate was lower than 5%, complying with China’s standard for medical polymer materials. The multiple hierarchical structure improved the interaction of blood cells and micro unit. The micro-nano effect prevented blood cells from mechanical injuring, adhering, and spreading. The coagulation cascade and microthrombus formation were markedly inhibited. The results might provide novel idea and method for fabrication of innovative medical engineering materials.
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