Abstract: Currently, P-value is at the core position for statistical analysis of biological data, as scientific inferences are made usually based on P-values. However, with the deepening of discussion of misunderstanding and the limitations of P-values, especially the anxiety about the reproducibility and replicability of scientific conclusions in the scientific community, an intense debate about the use of P-values has been raised especially. The misuse of P-values and the emergence of controversy over P-values can partly demonstrate the inadequacies in teaching of biostatistics in colleges and graduate schools. After introducing P-value controversy, reflections and enlightenments on biostatistics teaching are focused on from the current P-value controversy.

Key words: P-value, P-value controversy, biostatistics, teaching