Abstract: The development of molecular archaeology virtual simulation experiment project facing to both liberal arts and science major can not only make up for the shortage of practical learning opportunities of molecular biology for undergraduates majoring in archaeology, but also build a more professional practical learning platform for undergraduates majoring in biology. “Ancient DNA research” which could not be taught in the off-line classroom was eventually chosen as a content carrier after in-depth analyzing of the university’s discipline and technical advantage. The knowledge system and content structure were carefully designed according to the learning needs of both liberal arts and science students. The better teaching effect was achieved by designing differentiated teaching objective for liberal arts and science students and adopting the teaching tactics of “to strengthen practice in classroom after online learning”.

Key words: molecular biology, interdisciplinary, virtual simulation, experiment teaching, DNA extraction