Abstract: The important regulation roles of a process called ubiquitination in fruits to withstand environmental stress conditions were introduced in this work. Moreover, the constituent of ubiquitination system, especial the E3 ubiquitin ligase and the 26S proteosome that can specially recognized and hydrolyze the target proteins, and their modification process were described. Based on these, this work focused on the regulation and possible mechanism of ubiquitination modification process, taking the E3 ubiquitin ligase as core. This modification process helps fruits respond to different stresses like drought, salt, cold, heavy metals, aging, and even attacks from pathogenic bacteria. Additionally, the study highlighted several unresolved questions concerning how ubiquitination alterations work in fruits, including the inadequacy of ubiquitination-related genes and enzymes function identification, the spatial and temporal control of ubiquitination modification and its deubiquitination, and the lack of means to identify the ubiquitination modification sites. Ultimately, this work aimed to provide valuable insights into how modifications in ubiquitination contribute to the fruit quality formation and maintenance.

Key words: ubiquitination, fruit, stress responses, ubiquitin ligase