Abstract: The age of information technology promotes the process of online open courses in higher education and provides a new teaching model for the teaching reform of higher education in China.Progress graduate courses with the university biology frontier online integration construction are of important value significance, and mainly reflected in the following three aspects: providing an important opportunity for the graduate student’s independent learning, providing an important platform for the development of scientific thinking ability, and developing scientific thinking ability of providing an important platform.Based on the preliminary construction experience, the course construction needs to focus on the formulation of course objectives, the selection of characteristic teaching content and the implementation of teaching activities strategy.

Key words: biology frontier and progress, graduate courses, online and offline course construction