Abstract: No matter at which stage genetics develops, gene mapping is always one of the main contents to be studied. Gene mapping plays a very important role in the fields of biomolecular breeding, crop genetic improvement, disease diagnosis assisted by gene testing, targeted drug development and so on. With the development of sequencing data and big data, there are a variety of gene mapping methods, in which ‘ linkage’ and ‘ association’ are the main analytical ideas. Based on the characteristics of reproduction and genetic variation of animals, plants, humans, microorganisms and viruses, this paper mainly introduced the teaching cases of nuclear gene localization based on homologous recombination in the form of knowledge and mind mapping, in order to provide threads to be make for online and offline autonomous and exploratory learning of genetics.

Key words: genetics, genetic recombination, mutation, gene mapping, teaching design