Abstract: Gene fusion is one of the important causes of tumorigenesis, and almost half of all malignant tumors have the involvement of fusion genes. Exploring the characteristics of fusion genes has become a hot topic in life science and medical research. In this study, 11 632 gene fusion data were collected from ChiTaRS-3.1 database, from gene fusion, fusion gene distribution across the chromosome, and genes involved in fusion and the characteristics, as well as the analysis of the characteristics of the fusion gene using leukemia as an example. The results showed that gene fusion was dominated by chromosomal translocations, with more frequent mutations on chromosomes 11, 17 and 19 involving a total of 8733 genes, of which only 9% of genes participate in multiple fusion events, and 13% of gene fusion events were associated with leukemia. The distribution of gene fusion in the genome was non-random and concentrated. This study would provide new clues for the subsequent discovery of the mechanism of chromosomal gene fusion and its treatment and prevention of diseases.

Key words: chromosome recombination, fusion gene, cancer, leukemia