Abstract: Liver cancer is a critical disease that seriously injures the human life. Previous studies revealed that the traditional and folk Chinese medicine "natural plant antibacterial solution" (PAMs) has wide biological activities and effects on many diseases such as leukemia, psoriasis and inflammation. However, its effect on hepatoma cells, especially the molecular mechanism is not well understood. In this study, we confirmed that PAMs could inhibit the viabilities of HepG2 cells dependent on the concentration and time. PAMs enhanced the expression of caspase3, caspase8, caspase9 and p53, while it repressed the expression of Bcl-2. Furthermore, the nude mice HepG2 cell xenograft assay showed that PAMs significantly inhibited the tumor growth and promoted the apoptosis of HepG2 cells by downregulating FoxM1 expression merely by perfrication. Being a safe, effective and convenient candidate drug, PAMs is hoped to be used in the prevention and therapy of various diseases including liver cancer.

Key words: liver cancer, FoxM1, PAMs, traditional Chinese medicine