Table of Content

18 October 2026, Volume 43 Issue 5 Previous Issue   

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The evolution and future prospects of feedstock transition in the biomanufacturing industry ZHANG Wentao, GUO Feng, ZHANG Wenming 2026, 43 (5):  1.  doi: 10.3969/j.issn.2095-1736.2026.05.001 Abstract ( 18 )   PDF   Save Feedstock remains the central determinant of both the economic viability and carbon footprint of biomanufacturing. This review analyzed the evolutionary logic of feedstock transition—from First Generation (food-based) to Second Generation (non-food biomass) and Third Generation (C1 resources)—through the dual lenses of supply chain economics and process engineering. The resource constraints and economic volatility associated with 1G feedstocks, the engineering barriers related to biomass recalcitrance and logistics associated with 2G feedstocks, and the thermodynamic and mass transfer bottlenecks inherent in 3G technologies were examined. Based on a multidimensional assessment, it was concluded that the future landscape will feature feedstock diversification and coexistence of multiple feedstocks. Finally, the paper proposed key developmental pathways, including the reconstruction of distributed logistics systems, deep integration of renewable energy with biomanufacturing, and the standardization of carbon footprint accounting. Related Articles | Metrics

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Screening and denitrification characteristics of Halomonas sp. MY-11 under dual stress of high salinity and high ammonia nitrogen ZHANG Yuhong, LIU Jian, CAI Jiacheng, ZHANG Fang, JIANG Yueqing 2026, 43 (5):  11.  doi: 10.3969/j.issn.2095-1736.2026.05.011 Abstract ( 17 )   PDF   Save A heterotrophic nitrification-aerobic denitrification （HN-AD） strain,Halomonassp. MY11, with tolerance to high salt and high ammonia nitrogen was successfully screened from a chemical wastewater treatment plant. The growth characteristics and denitrification performance of strain MY-11 were investigated by a one-factor-at-a-time experimental design, and the strain was able to grow and exhibit HN-AD activity under different environmental conditions, and the optimal culture conditions were determined as follows: carbon source of sodium succinate, C/N of 10－18, pH 7－9, shaker speed of 140－220 r/min, incubation temperature of 30－34 ℃, inoculum amount of 1%－5% （volume ratio）, and salinity of 2%－8%. Under these conditions, the removal efficiency of the strain for both NH+4-N and NO－3-N reached more than 99% within 30 h. The strain could grow under high-salt （4% salinity） and high-ammonia-nitrogen （1200 mg/L） conditions, exhibited high nitrogen removal efficiency, and could also adapt to various inorganic salt environments. It is demonstrated that strain MY-11 had excellent HN-AD performance and showed significant application value in the field of biological treatment of high-salt and high-nitrogen industrial wastewater. Related Articles | Metrics

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#br# Study on the prediction of β-1,3-glucan content in mycelium of Ganoderma spp. based on infrared spectroscopy CHEN Hongxia, SHI Meiyi, LI He, XIAO Shijun, HAN Xuerong 2026, 43 (5):  19.  doi: 10.3969/j.issn.2095-1736.2026.05.019 Abstract ( 16 )   PDF   Save This study employed near-infrared spectroscopy (NIRS) to acquire spectral data from 160Ganodermaspp. mycelium samples. The β-1,3-glucan content was measured using the aniline blue fluorescence method as the reference value. A predictive model for β-1,3-glucan content inGanodermaspp. mycelium was established based on partial least squares regression (PLSR). After excluding outliers, 150 valid samples were retained. Thirteen characteristic wavelengths were extracted using the competitive adaptive reweighted sampling (CARS) algorithm. Five machine learning algorithms were used for modeling,including partial least squares regression (PLSR), back propagation neural network (BPNN), extreme learning machine (ELM), support vector machine (SVM) and random forest (RF). The PLSR model achieved the highest accuracy (R2=0.946, RMSEP=0.545, RPD=4.303). Predictions and validation of β-1,3-glucan content in 20Ganodermaspp. mycelium samples using this model showed satisfactory accuracy and robustness (R2=0.8425, RMSEP=0.8025, RPD=2.4121, all exceeding 2.4). This study developed a practical β-1,3-glucan assay method, enabling rapid and non-destructive quantitative detection of β-1,3-glucan inGanodermaspp. mycelium samples. Related Articles | Metrics

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Enzymatic characteristics of polygalacturonase produced by an Aspergillus fumigatus strain and its application in fallen-leaf hydrolysis#br# ZHONG Xuan, WANG Qingyan, WU Jingtao, ZHENG Mengting, QIN Yan, XIAN Liang 2026, 43 (5):  27.  doi: 10.3969/j.issn.2095-1736.2026.05.027 Abstract ( 16 )   PDF   Save The search for a polygalacturonase suitable for fallen leaf hydrolysis is crucial for accelerating the natural nutrient cycle. This study involved collecting corresponding samples to increase the possibility of obtaining target microorganisms, determining enzymatic characteristics to assess the adaptability of polygalacturonase, and hydrolyzing fallen leaves to measure the application potential of the isolated strain. In the study, a polygalacturonase-producing strain, F21-5, was isolated from decaying fallen leaves and identified asAspergillus fumigatusbased on morphological characteristics and internal transcribed spacer sequence analysis. The obtained F21-5 crude polygalacturonase showed an optimal pH of 5.5, retained more than 80% of its activity within the pH range of 4.0－6.0, and remained stable across pH 3.0－11.0. Furthermore, the enzyme exhibited maximum activity at 60－65 ℃ and maintained stability at 40 ℃. The activity of F21-5 crude polygalacturonase was markedly inhibited by Ca2+ and Cu2+ at the tested concentrations. Hydrolysis of fallen leaves increased the reducing sugar concentration by 503.47%±37.26% in leaves ofMagnolia denudata, 416.07%±0.48% inTectona grandisL.f., 227.03%±0.46% inArtocarpus heterophyllusLam., and 105.60%±0.27% inDracontomelon dao. These results demonstrate thatA. fumigatusF21-5 produces a robust polygalacturonase with strong hydrolytic activity, indicating its potential role in leaf degradation and natural nutrient cycling. Furthermore, polygalacturonase produced byA. fumigatusF21-5 represents a high-potential biocatalyst for industrial-scale pectin bioconversion applications. Related Articles | Metrics

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Effect of the cit1 gene on Aspergillus flavus development and aflatoxin biosynthesis XIE Chunlan, YANG Kunlong, QIN Bei, XIE Rui 2026, 43 (5):  34.  doi: 10.3969/j.issn.2095-1736.2026.05.034 Abstract ( 12 )   PDF   Save Aflatoxin B1 （AFB1）, a highly carcinogenic secondary metabolite produced byAspergillus flavus, poses a serious threat to human health and agricultural economic development. CIT, a citrate synthase encoded by thecit1gene inA. flavus, catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate in the first step of the tricarboxylic acid （TCA） cycle, which is involved in the regulation of eukaryotic development, cell apoptosis, and cancer cell proliferation. To provide new insights for effective prevention and control ofA. flavus,the functions of Cit1 were explored in this study. Bioinformatics analysis indicated thatA. flavusCit1 displayed high similarity to orthologs from otherAspergillusspecies. The deletion ofcit1was constructed using homologous recombination methodology. Phenotypic assays and qRT-PCR analysis indicated that the deletion ofcit1affectedA. flavusdevelopment and pathogenicity. The colony diameter of the Δcit1strain was significantly reduced, and the conidial number and morphology in Δcit1differed from those of the wild type （WT） strain. Sclerotial formation was disrupted in Δcit1. Moreover, AFB1 production in Δcit1was decreased. Pathogenicity toward maize kernels in Δcit1was sharply attenuated compared with that of WT. Collectively, thecit1gene was crucial for sclerotial formation, and was also involved in various biological processes includingA. flavusvegetative growth, aflatoxin biosynthesis, and pathogenicity. Related Articles | Metrics

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Structural and functional analysis of the key genes gadA and gadC involved in γ-aminobutyric acid synthesis in Enterococcus lactis FSUH-1 NIE Manru, LI Lianjiao, ZHENG Jianwei, YE Manshi, ZHONG Xianfeng, HUANG Guidong 2026, 43 (5):  43.  doi: 10.3969/j.issn.2095-1736.2026.05.043 Abstract ( 11 )   PDF   Save This study focused onEnterococcus lactisFSUH-1 to investigate the characteristics of its γ-aminobutyric acid （GABA） synthesis system. It demonstrated that FSUH-1 possessed the ability to produce glutamate decarboxylase （GAD）. Potential key functional genes in its genome were amplified, and were verified that FSUH-1 contained the key genesgadAandgadC, which were essential for GABA synthesis in lactic acid bacteria. Bioinformatics methods were employed to analyze and predict the structure and function of the proteins encoded bygadAandgadC. It was found that the GadA protein was a hydrophilic protein without transmembrane regions or a signal peptide, indicating that it was an intracellular protein. It contained the GAD （TIGR01788） domain and was confirmed to catalyze the production of GABA from glutamate. The GadC protein was identified as a hydrophobic protein with transmembrane regions but no signal peptide, and was classified as a transmembrane protein. It contained the GadC （TIGR00910） domain and was predicted to mediate functions such as substrate transport and signal transduction. The tertiary structures of the GadA and GadC proteins were superimposed on and compared with the corresponding protein structures fromEscherichia coliandLactobacillusCGMCC 1306. Results showed that the core regions of their tertiary structures were consistent, indicating that the GadA and GadC proteins in this strain were highly conserved and could mediate the catalytic synthesis of GABA. Related Articles | Metrics

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Three newly recorded angiosperms in Hubei Province ZHU Wenlong, ZHAO Wanyu, JIN Tao, CHEN Xitang, TAN Fei, LIU Hong 2026, 43 (5):  50.  doi: 10.3969/j.issn.2095-1736.2026.05.050 Abstract ( 15 )   PDF   Save This study aimed to enhance the understanding of wild plant resources in Hubei Province through field investigations in Hubei Jiugongshan National Nature Reserve. After identification, three angiosperms were confirmed as newly recorded species in Hubei Province:Morinda nanlingensis Y. Z. Ruan,Ilex wugongshanensisC. J. Tseng ex S. K. Chen & Y. X. Feng, andWikstroemia glabraW. C. Cheng. The discovery of these newly recorded species provides a new basis for research on local plant resources. It also highlights the rich biodiversity of the Hubei Jiugongshan National Nature Reserve. Voucher specimens are deposited in the Herbarium of South-Central Minzu University （HSN）. Related Articles | Metrics

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Resource survey of Kirengeshoma palmata in Anhui Qingliangfeng National Nature Reserve YANG Meng’en, CHEN Yue, TANG Yunlong, WANG Jian, SHAO Jianwen 2026, 43 (5):  54.  doi: 10.3969/j.issn.2095-1736.2026.05.054 Abstract ( 14 )   PDF   Save Kirengeshoma palmata, an endemic relict plant in East Asia, is a robust perennial erect herbaceous species and is listed as a Class Ⅱ National Key Protected Wild Plant of China. The Anhui Qingliangfeng National Nature Reserve represents one of its core distribution areas. However, the current status of theK. palmatapopulation in this area remains unclear. In this study, the current population status ofK. palmatain this nature reserve and its surrounding areas was investigated using the line-transect method. A total of 826 clumps distributed across 67 patches were documented, primarily concentrated in four areas at elevations between 900 and 1400 m. Patches with more clumps tended to occur at higher altitudes. In terms of plant type composition across the four areas, “non-flowering clumps” and “flowering clumps” were dominant, while “Juvenile” and “degenerated clumps” were relatively scarce. The number of branches per clump was mostly between one and three. Key differences among the areas included: a relatively high proportion of degenerated clumps in the Zhanlingwanyuan Area; the Shibalongtan Area predominantly had clumps with 2－3 branches, whereas other areas were dominated by single-branch clumps; the Shibalongtan Area also had the highest average number of flowering branches per clump, while the Xiejia Area had the lowest. In the context of global warming, the cool-preferring biological characteristics ofK. palmataand its limited upward shift within a confined elevation range are likely the primary factors endangering its survival. Corresponding conservation recommendations have been proposed based on this analysis. Related Articles | Metrics

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Advances in plant priming technology #br# LU Meirong, LIU Haonan, LI Zhongguang 2026, 43 (5):  60.  doi: 10.3969/j.issn.2095-1736.2026.05.060 Abstract ( 17 )   PDF   Save Seed priming is a low-cost, short-duration, and environmentally friendly plant priming technique. As a key pretreatment strategy, it enhances seed germination and plant stress resistance by precisely regulating seed hydration status and physiological activity. Plant priming technology based on seed priming plays a significant role in reducing dependence on chemical fertilizers and pesticides, thereby promoting sustainable agricultural development. This review systematically introduced the origin, current progress, and future directions of plant priming technology, with a focus on establishing a multidimensional classification system based on the target organ, priming method, and priming agent type. It also summarized modern priming techniques and illustrates their notable effects through concrete examples, including improvements in seed germination rate, seedling uniformity, and plant stress tolerance. Moreover, this article delved into the physiological, biochemical, and molecular mechanisms underlying priming-induced stress tolerance, including the regulation of material and energy metabolism, activation of antioxidant and osmoregulatory systems, and involvement of epigenetic modifications. Furthermore, plant priming technology was expected to integrate with emerging technologies, advancing toward precision and intelligence, and thus providing new perspectives for seed technology and smart agriculture. Related Articles | Metrics

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Research progress on the allelopathic effects of toxic weeds in grasslands and their development and utilization LI Nufen, ZHANG Jiadi, HUA Wei, LIU Kailin, YANG Haona 2026, 43 (5):  67.  doi: 10.3969/j.issn.2095-1736.2026.05.067 Abstract ( 15 )   PDF   Save The rapid spread of toxic weeds on grasslands poses a serious threat to the health of grassland ecosystems and the sustainable development of animal husbandry, making it a hot topic in grassland ecology research. Among them, allelopathy is one of the key internal mechanisms for their invasion and expansion. Exploring the allelopathy of toxic weeds on grasslands is of guiding significance for curbing grassland degradation and promoting the ecological restoration of degraded grasslands. This paper reviewed the research progress on allelopathy of toxic weeds on grasslands and briefly summarized their comprehensive utilization. The research found that the main allelochemicals of toxic weeds on grasslands included phenolic compounds and their derivatives, terpenoids and alkaloids, etc. These substances could not only harm grassland ecosystems by inhibiting the growth of high-quality forage and changing soil microbial communities, but also have great potential in the development of new biological pesticides, therapeutic agents and feed applications due to their strong biological activity. Finally, this paper proposed that multi-omics technologies should be integrated to analyze in depth the allelopathy mechanism of toxic weeds on grasslands, promoted their comprehensive development and utilization, and provided new ways for the sustainable development of grassland ecosystems and efficient utilization of resources. Related Articles | Metrics

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Study of glucose detection with peroxidase-like activity of bromelin LI Quanfa, TENG Yimeng, ZHOU Rongjie, LIU Ya’nan, WANG Baojuan 2026, 43 (5):  74.  doi: 10.3969/j.issn.2095-1736.2026.05.074 Abstract ( 11 )   PDF   Save his study demonstrated for the first time that bromelin exhibited peroxidase-like activity. Enzymatic characterization confirmed that the optimal temperature and pH for its peroxidase-like activity were respectively 40 ℃ and 5.0, and with H2O2and TMB as substrates, the specific enzyme activities were 16.58 U/mg and 18.41 U/mg, respectively. Furthermore, a cascade catalytic system was constructed by coupling bromelin with glucose oxidase, enabling broad-range and highly sensitive glucose detection with a linear range of 5－400 μmol/L and a detection limit of 1.5 μmol/L. Additionally, the system demonstrated excellent selectivity and resistance to interference for glucose detection, enabling its effective application in the analysis of human blood and urine samples. Therefore, this research not only provided an efficient, sensitive, and visual detection method for diabetes diagnosis, characterized by operational simplicity and excellent cost-effectiveness, but also successfully expanded the application scope of bromelain in enzymology, bringing new vitality into enzymatic research and applications. Related Articles | Metrics

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#br# Development of a bioluminescence resonance energy transfer（BRET）-based assay system for detecting the activated state of CDC42 #br# ZHOU Jiamin, LIN Weidong, WANG Xuefei, ZHANG Qian, CUI Yunxia, ZHAO Mingzhu, ZHANG Jian 2026, 43 (5):  81.  doi: 10.3969/j.issn.2095-1736.2026.05.081 Abstract ( 15 )   PDF   Save CDC42 GTPase is overexpressed in multiple tumors and drives oncogenic progression by activating signaling pathways associated with cell proliferation, angiogenesis, and metastasis. To address the limitations of current methods for detecting cell division cycle 42 （CDC42）activation status, this study developed a high-throughput screening system based on bioluminescence resonance energy transfer （BRET）technology for rapid assessment of CDC42 activation. By coupling CDC42 with renilla luciferase （RLUC）and PAK1 with enhanced green fluorescent protein （EGFP）, a BRET detection system was constructed. Systematic optimization of protein fusion strategies （N-terminal or C-terminal fusion of RLUC/EGFP）and dual-plasmid transfection ratios （nine combinations）revealed that the combination of CDC42-C-EGFP with PAK1-C-RLUC （9∶1 ratio）significantly enhanced BRET signals, increasing the BRET ratio from 0.05 to 0.25 （4-fold increase）, thereby substantially improving detection sensitivity. Using this system, concentration-dependent inhibitory effects of known inhibitors （ML141, ARN25062, ARN24928）were validated. Among these, ARN25062 exhibited the strongest inhibitory potency and also demonstrated the strongest suppression of hepatocellular carcinoma cell proliferation, migration, and invasion, consistent with cell-based assay results. These findings confirmed that the established BRET system effectively characterized CDC42 inhibitor activity. The optimized BRET-based platform provided a critical tool for investigating CDC42 regulatory mechanisms and developing targeted therapeutics, while offering novel strategies for functional studies and drug discovery of small GTPases （e.g., Rho family proteins）. Related Articles | Metrics

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Screening and application of high-efficiency degradation bacteria for N,N-dimethylacetamide YANG Yuanyuan, LEI Ting, SHEN Chao 2026, 43 (5):  88.  doi: 10.3969/j.issn.2095-1736.2026.05.088 Abstract ( 19 )   PDF   Save To address the issue of biochemical degradation of N, N-dimethylacetamide （DMAc） in membrane wastewater, a bacterial strain designated DC-1, which is capable of effectively degrade DMAc, was isolated from the activated sludge of the Guiyang Maijiaqiao municipal wastewater treatment plant. Based on morphological observations, physiological and biochemical characterization, as well as phylogemetic analysis of the 16S rDNA gene sequence, it was identified asArthrobacter protophormiae. The effects of inoculum size, incubation temperature, and pH on the efficiency of DMAc degradation by DC-1 were investigated using a one-factor-at-a-time approach followed by response surface methodology based on the Box-Behnken design. The results indicated that the optimal temperature for bacterial growth and DMAc degradation was 29 ℃, the optimal pH was 7.8, and the optimal inoculum size was 13%. Under the optimized conditions, a degradation rate of over 90% was achieved for DMAc at an initial volume fraction of 2% within 144 h. Additionally, the strain exhibited certain degradation capabilities for the structurally similar compound dimethylformamide（DMF）. These findings demonstrated that strain DC-1 held considerable potential for the bioremediation of DMAc-contaminated wastewater, particularly in membrane manufacturing industries. Related Articles | Metrics

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Design of a computational module for experiment teaching in protein science and engineering based on high-performance computing WANG Qiong, ZHANG Ling, LING Mengying, YAN Zhengfei, NIE Yao 2026, 43 (5):  97.  doi: 10.3969/j.issn.2095-1736.2026.05.097 Abstract ( 13 )   PDF   Save 　This course holds a significant position in the comprehensive professional talent training system. This experiment relies on a high-performance computing platform, incorporating AlphaFold2 and Schrdinger software into the experimental teaching of protein science and engineering. By utilizing bioinformatics methods such as protein structure prediction, molecular docking, and molecular dynamics simulation, students can gain deeper insights into the catalytic mechanisms of proteins. The teaching experiment employs a differentiated instruction approach and incorporates assessment methods based on individual performance and group presentations. This design aims to enhance students’ abilities in self-directed learning, teamwork, information retrieval, tool application, problem analysis, and knowledge exploration. By analyzing students’ evaluations of teaching, we can further improve teaching content and enhance teaching effectiveness. This course serves as a valuable reference for the innovation of teaching experiments in similar courses such as enzyme engineering. It not only provides students with the opportunity to learn and use advanced scientific research tools but also plays a significant role in enhancing learning interest, improving teaching effectiveness, and cultivating innovative talents with interdisciplinary backgrounds. Related Articles | Metrics

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Practice of the application of the digital interactive exploratory method (DIEM) in the teaching of biochemistry #br# LEI Lei, WANG Huijuan, GUAN Feng, LI Xiang, TAN Zengqi 2026, 43 (5):  105.  doi: 10.3969/j.issn.2095-1736.2026.05.105 Abstract ( 11 )   PDF   Save As a core fundamental course in life sciences, biochemistry has long faced teaching challenges due to its highly abstract theories and complex knowledge system, which often lead to insufficient learning motivation and cognitive overload among students. To address these issues, this study proposed the digital interactive exploratory method (DIEM), a novel teaching model that integrates digital intelligent tools, multi-dimensional interactive mechanisms, and exploratory learning tasks. The study was conducted in the biochemistry course of the College of Life Sciences at Northwest University, where students were divided into an experimental class (DIEM model) and a control class (traditional lecture-based model). The DIEM was implemented through a systematic approach involving “pre-class intelligent guidance, in-class interactive learning, and post-class project-based extension”. Empirical results indicated that DIEM significantly improved the experimental class students’ exam scores, learning interest, collaboration skills, and self-directed learning abilities. This study not only provided a replicable solution for Biochemistry teaching reform but also effectively broke through the cognitive barriers of traditional science teaching, offering theoretical references for educational digital transformation. Related Articles | Metrics

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Digital teaching reform in food biochemistry based on a “phenomenon-mechanism-application” progressive model LIU Shanshan, QI Gaozhan, LU Liping, GAO Dandan 2026, 43 (5):  110.  doi: 10.3969/j.issn.2095-1736.2026.05.110 Abstract ( 13 )   PDF   Save Food biochemistry is a core foundational course for food-related majors, yet its teaching is often challenged by abstract theoretical knowledge, microscopic biochemical processes, insufficient classroom interaction, and weak knowledge transfer. To address these problems, this study constructed a digitally supported progressive teaching model characterized by a “phenomenon-mechanism-application” based on the Chaoxing Learning Platform. Centered on core knowledge modules of food biochemistry, the model integrated resource push, AI-assisted Q&A, multimedia visualization, and virtual simulation into a connected teaching support system across pre-class, in-class, and post-class stages. A comparative teaching study was conducted with the 2024 experimental class and the 2023 control class in the food science and engineering program at Northwest Minzu University. The results showed that the model enhanced pre-class learning, classroom interaction, course assignments, stage tests, and overall course performance, with particularly notable effects on classroom engagement, depth of mechanistic understanding, and knowledge transfer ability. These findings suggested that the digital reform of food biochemistry should be grounded in core disciplinary content and supported by the coordinated use of digital platforms, multimedia technology, AI-assisted learning, and virtual simulation. Related Articles | Metrics

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Enhancing graduate students’ critical thinking ability through the BOPPPS teaching model ZOU Qin, SUN Lichao, CHEN Zhenya, MA Xiaoyan, GUO Shuyuan, HUO Yixin 2026, 43 (5):  115.  doi: 10.3969/j.issn.2095-1736.2026.05.115 Abstract ( 12 )   PDF   Save This study focused on CRISPR-Cas9 gene editing technology as an instructional framework and applied the BOPPPS teaching model to address the training objectives of graduate students at the School of Life Science, Beijing Institute of Technology. Through comparative research between experimental and control classes, the study systematically explored the model’s effectiveness in cultivating critical thinking skills among graduate students. The findings demonstrated that the BOPPPS model significantly enhanced students’ critical thinking abilities. Students in the experimental class engaged in participative learning, case studies, and classroom debates, effectively applying analytical, evaluative, and reasoning skills to explore the scientific principles, application limitations, and ethical controversies of gene editing technology while proposing innovative perspectives. In contrast, the traditional lecture-based approach, though efficient in knowledge delivery, showed notable limitations in fostering higher-order cognitive skills such as critical thinking. The research also identified challenges in implementing the BOPPPS model, including overly intensive task design and insufficient time allocation for in-depth cognitive training. To address these issues, the study proposed strategies such as optimizing task design, strengthening critical thinking exercises, and establishing a diversified evaluation system to refine the mechanism for cultivating critical thinking in graduate education. These findings provided a theoretical foundation and practical references for deepening graduate education reform and nurturing innovative talents with robust critical thinking capabilities in the context of intensifying global technological competition. Related Articles | Metrics

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Innovation and practice of the construction model of a full English-medium biology science major from the perspective of research feedback to teaching FAN Jianhua, SUN Liyun, ZHOU Mian, WU Hui, MA Yushu, OUYANG Liming, WANG Qiyao, WU Haizhen, FAN Liqiang 2026, 43 (5):  120.  doi: 10.3969/j.issn.2095-1736.2026.05.120 Abstract ( 11 )   PDF   Save In response to the strategic demands of the “Double First-Class” Initiative, Healthy China and Green China, the Bioscience Major of East China University of Science and Technology （ECUST） has been exploring and implementing a “new model for the construction of full English-medium majors with research feedback to teaching as the core grasp” since 2017. With the development of an international curriculum system centered on research feedback to teaching and the integration of scientific research into teaching as a key approach, the team has built a research-oriented international faculty structure consisting of permanent and visiting members. By means of honors courses, case studies and small-class teaching, the latest scientific research achievements and frontier advances are fully integrated into all links of teaching, it focuses on cultivating international talents and enhancing students’ academic innovation ability. Many years of practice have shown that research feedback to teaching runs through the whole process of program construction; this model has significantly strengthened students’ professional identity, scientific research innovation ability and international competitiveness, providing valuable experience for the internationalization of biology-related majors. This study offers a replicable research-feedback-based practical paradigm for the internationalization of teaching in domestic science majors. Related Articles | Metrics

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Creation of the virtual simulation experiment course on Ti-Chou Tung’s nuclear-cytoplasmic interaction theory and its intelligent agent SHI Yongxiang, LIU Boyang, ZHANG Chuanxin, XU Yuxin, CHEN Guang’an, WU Keliang 2026, 43 (5):  126.  doi: 10.3969/j.issn.2095-1736.2026.05.126 Abstract ( 11 )   PDF   Save This study presented an innovative virtual simulation teaching system—cell nuclear reprogramming software V2.0 and its intelligent agent—developed by integrating Ti-Chou Tung’s nuclear-cytoplasmic interaction theory with multidisciplinary approaches and modern educational technology. The software system comprised 10 sub-experiments. Through 3D modeling, dynamic simulation, and intelligent evaluation technologies, it fully reproduced the entire process of preparing and handling experimental mice, using lymphocytes as nuclear donors, collecting MⅡ stage oocytes for nuclear transfer, and finally transplanting the reconstructed embryos into the oviducts. Currently deployed online (Access: http://www.vs.sdu.edu.cn/virexp/xbhyz), post-implementation surveys via Wenjuanxing confirmed that the course meet the “two properties and one degree” standard, it enhanced learner engagement through flexible pedagogy, and significantly improved students’ interest, competencies, and innovative thinking. An intelligent agent embedded with continuous AI-powered upgrads. This project established a model for preserving foundational scientific theories while cultivating interdisciplinary talent in cutting-edge biomedicine. Related Articles | Metrics