Abstract: Asthma is a complex and heterogeneous disease with many different clinical phenotypes. Typical clinical manifestations are recurrent cough, chest tightness, wheezing, shortness of breath, more than nighttime, more self-remission or use of drugs(Such as short-acting beta-agonist salbutamol) can be relieved, which has the characteristics of recurrent， and continuous progress has become a serious public health problem. Among them, inhaled corticosteroids(ICS) are the most effective treatments recommended for the long-term control of asthma, but even with high-dose hormone therapy, combinaed with long-acting β2 receptor agonists or leukotriene modulators，the disease is still difficult to control some to patients, and the heterogeneity of asthma caused many asthma patients respond to conventional anti-asthma treatment is an important reason. Therefore, specific targeting therapy for different asthma phenotypes is an important direction for asthma research in the future. This article reviews several common targeted therapies for asthma phenotypes.

Key words: asthma, phenotype, targeted therapy