Abstract: The innate immune system recognizes pathogen-associated molecular patterns(PAMPs) through PRRs. Upon sensing of these PAMPs, these PRRs trigger a series of signaling events and lead to the subsequent induction of pro-inflammatory cytokines and type I interferons(IFNs). Ubiquitination is an important post-translational modification that plays a critical role in the innate immune signaling pathway. TRIMs belong to E3 ubiquitin ligases and are important in the innate immune system. Here the recent advances were summarized on the functions and molecular mechanisms of TRIMs in TLRs, RLRs and DNA sensors signaling pathway, and the new insights for regulation of innate immune signaling were provided.

Key words: innate immunity, TRIM, signaling transduction