Abstract: tEPHA3 is a member of the ephrin receptor family, which composes the largest subgroup of the known receptor tyrosine kinases. EPH receptors and their ephrin ligands are essential for a variety of biological processes such as cell adhesions and repulsion, cell migration, axon guidance and angiogenesis et al, and they are implicated in cancer metastasis and invasion. In this study, a novel mutation of Epha3 gene was unexpectedly discovered in liver cancer, where its cytoplasmic SAM domain was incomplete. It is supposedly a novel way for Epha3 regulation in liver cancer.

Key words: EPHA3, tumour, cancer, receptor tyrosine kinase