Abstract: CD4+ helper T cells (Th cells) differentiate into different cell subsets in order to resist or adapt to the environment changes under the condition of antigen stimulation and body micro-environment, and the process of cells differentiation is controlled by the complex regulatory network of cytokines and transcription factors.Epigenetics is a science that does not involve the change of DNA sequences and changes gene expression such as DNA methylation and chromatin structure, and passes between the parental and filial generation.Epigenetics have an important influence on the differentiation regulation of immune cells and the heritability of T helper cell lineage. 

Key words: epigenetics, T helper cells, differentiation