Abstract: In recent years, heavy ion beam has had a wide application and get some good effects in microbial breeding as a new radiation mutation source because of some advantages, such as light damage, high mutation rate, wide mutation spectrum, higher energy transmission line density, typical Bragg effect, smaller oxygen increasing ratio. However, the mutation mechanism of the new mutation resource has not been explored clearly because of the complexity of interaction between heavy ion beam and microorganism, and the differences in different microorganism. The unknown in mutation mechanism hindered the combination of heavy ion mutation and genetic engineering strain modification technique, and thus limited the development of reverse metabolic engineering. The research progress of the mutation mechanism of heavy ion on microorganism was introduced in the paper in order to provide a reference for the application of heavy ions in strain modification.

Key words: font-size:medium, ">heavy ion； microorganism； mutagenesis mechanism