跨膜蛋白43的研究进展

doi:10.3969/j.issn.2095-1736.2019.04.074

Research progress of transmembrane protein 43

1. The Key Laboratory of Bioengineering and Biotechnology of the state Ethnic Affairs Commission, Northwest Minzu University, Lanzhou 730030; 2. College of Life Science and Engineering, Northwest Minzu University,Lanzhou 730030; 3.Gansu Engineering Research Center for Animal Cell, Lanzhou 730030, China

Online:2019-08-18 Published:2019-08-18

Abstract

Abstract: Transmembrane protein 43 is a nuclear membrane protein that is highly conserved among species. It is located in the core membrane and endoplasmic reticulum and has a large hydrophilic domain. Epidemiological studies have found that mutations of TMEM43 can lead to arrhythmogenic right ventricular cardiomyopathy (ARVC) and Emery-Dreyfus muscular dystrophy (EDMD).At present, there are still some difficulties in the diagnosis and treatment of this disease.In addition, TMEM43 also interacts with other transmembrane proteins, but its function and related pathogenic mechanisms are poorly understood. In this review, the role of TMEM43 in related diseases and the interaction between TMEM43 and associated proteins were summarized.

Key words: transmembrane protein 43, arrhythmogenic right ventricular cardiomyopathy, emery-dreyfus muscular dystrophy, nuclear membrane protein

CLC Number:

ZHAO Ke-xue,LIANG Hao-qin, LI Qiong-yi, FENG Ruo-fei. Research progress of transmembrane protein 43[J]. , doi: 10.3969/j.issn.2095-1736.2019.04.074.

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Research progress of transmembrane protein 43

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