Abstract: Brain aging is associated with impairments in learning and memory, which can be explained partly by alterations in synaptic structure and function rather than neuronal loss. Postsynaptic density protein 95 (PSD-95) is a major scaffolding protein in postsynaptic density and is important for maintaining the synaptic structure and plasticity. PSD-95 is considered to be associated with brain aging in recent studies. Thus, we reviewed the relationship of PSD-95 and brain aging, mainly focusing on impairments in learning and memory, hoping to provide a new sight for further researches in the mechanisms of brain aging and in preventing the related diseases.

Key words: brain aging, learning and memory, synapse, postsynaptic density protein 95