生物学杂志

生物学杂志 ›› 2026, Vol. 43 ›› Issue (4): 80-.doi: 10.3969/j.issn.2095-1736.2026.04.080

• 研究报告 • 上一篇    下一篇

虾青素减轻帕金森病线虫神经损伤效应的研究

肖琳飞1,2， 江　昊2,3， 邵长胜2， 黄　青1,2   

  1. 1. 中国科学技术大学 研究生院科学岛分院， 合肥 230026； 2. 中国科学院合肥物质科学研究院智能
    机械所， 合肥 230031； 3. 安徽农业大学 生命科学学院， 合肥 230036
  • 出版日期:2026-08-18 发布日期:2026-08-21
  • 通讯作者: 黄青，博士，研究员，研究方向为生物物理学，E-mail：huangq@ipp.ac.cn
  • 作者简介:肖琳飞，硕士研究生，研究方向为生物与医药，E-mail：xinlife@mail.ustc.edu.cn
  • 基金资助:
    国家自然科学基金项目（11775272）

Astaxanthin confers neuroprotection in a Caenorhabditis elegans model of Parkinson’s disease 

XIAO Linfei1,2, JIANG Hao2,3, SHAO Changsheng2, HUANG Qing1,2   

  1. 1. Science Island Branch of Graduate School, University of Science and Technology of China, Hefei 230026, China;
    2. Institute of Intelligent Machinery, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031,
    China; 3. School of Life Sciences, Anhui Agricultural University, Hefei 230036, China
  • Online:2026-08-18 Published:2026-08-21

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摘要： 本研究选用秀丽隐杆线虫为材料，通过6-羟多巴胺（6-hydroxydopamine，6-OHDA）损伤多巴胺能神经元，构建帕金森病线虫模型（PD线虫），探讨了虾青素（astaxanthin，AST）对PD线虫氧化应激、脂肪代谢以及多巴胺能神经元介导的运动能力的影响，并结合转录组比较分析揭示其响应机制。研究发现，虾青素不仅可以改善氧化应激的水平、恢复PD线虫多巴胺能神经元活性以及运动能力、影响脂质代谢过程，还通过调控CELE_F10D2.9、CELE_F38E1.5、CELE_K08F4.6等基因的表达，从而对PD线虫神经发挥保护作用。

关键词: 虾青素, 帕金森病线虫, 氧化应激, 转录组, 神经保护

Abstract: Caenorhabditis eleganswas employed as a model organism to establish a Parkinson’s disease （PD） model by inducing dopaminergic neurodegeneration with 6-hydroxydopamine （6-OHDA）. This study investigated the effects of astaxanthin （AST） on oxidative stress, lipid metabolism, and dopaminergic neuron-mediated locomotion in PD worms, and utilized transcriptomic analysis to elucidate the underlying mechanisms. The results demonstrated that astaxanthin not only ameliorated oxidative stress, restored dopaminergic neuron function, improved locomotor capacity, and modulated lipid metabolism, but also exerted neuroprotective effects against 6-OHDA-induced toxicity by regulating the expression of key genes, includingCELE_F10D2.9, CELE_F38E1.5, andCELE_K08F4.6. These findings suggested that astaxanthin might serve as a potential therapeutic agent in PD by modulating specific genetic pathways.

Key words: astaxanthin, Parkinson’s disease nematode model, oxidative stress, transcriptome, neuroprotection

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