Abstract: Human chromosome karyotype analysis is one of the most important technology in prenatal and genetic disease diagnosis, widely used in clinic, so it is significant to students′ practical skills in medical genetics course. In our open laboratory construction, a comprehensive teaching design on human chromosome karyotype analysis was explored, and "level-up" experimental learning was used into intensive training among students. This practice method showed a great of achievements to stimulate students′ learning interest and develop clinical application and innovation ability and it might give a new teaching reform direction about comprehensive design experiment.

Key words: leve-up, karyotype analysis, comprehensive design experiment, teaching