生物学杂志

Journal of Biology ›› 2022, Vol. 39 ›› Issue (1): 75-.doi: 10. 3969/ j. issn. 2095-1736. 2022. 01. 075

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Effect of cornus iridoid glycosides on mouse vascular endothelial cells

  

  1. 1. School of Life Science and Technology, Henan Institute of Science and Technology, Xinxiang 453003, China;
    2. State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, CAS, Beijing 100190, China;
    3. Beijing Biosis Healing Biological Technology Co. , Ltd, Beijing 100026, China
  • Online:2022-02-18 Published:2022-02-15

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Abstract: The cornus iridoid glycosides ( CIG ) were extracted and detected, and the influence of CIG to vascular endothelial cell was studied. The cornus was extracted by ultrasonic and treated with D101 macroporous resin to remove the impurities such as pigment and sugar, and the extraction was compared with four standards using HPLC-MS. The effects of CIG on mouse vascular endothelial cell proliferation,cell morphology and cell apoptosis were studied. The results showed that, 0. 5-50 μg/ mL CIG could promote the vascular endothelial cell proliferation and inhibit cell atrophy and apoptosis caused by high glucose.Cell damage and apoptosis were important for thrombosis. Cornus as the medicine and food could reduce the risk of thrombosis.

Key words: Cornus officinalis, iridoid glycoside, HPLC-MS, vascular endothelial cell, cell apoptosis

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