Abstract: The purpose of experimental course for the integrated course of cellular and molecular basis was to improve students’ practical ability to integrate and flexibly apply the key and difficult points they have learned, and to cultivate their innovative scientific research thinking in proposing and solving problems. This study analyzed the teaching status of this course, including problems such as rigid teaching methods, redundant and poor continuity of teaching content, outdated experimental teaching content, and a single method for evaluating teaching effect. The reform practices of experimental courses was explored from three aspects: course design, experimental content, and objectives of course assessment. Based on clinical cases-oriented teaching model to cultivate innovation and entrepreneurship abilities among college students in the new era, a “scenario-based” experimental class was designed. The experimental teaching content was also reconstructed based on the training mode of cultivating scientific research thinking. The establishment of a multi-dimensional assessment method based on scientific thinking and supplemented by experimental skills improved the effectiveness and innovation of teaching design, promoted the course construction of cellular and molecular basis, and effectively cultivated students’ innovative scientific research thinking and research literacy. This study provided new ideas and practical basis for cultivating medical talents with scientific innovation spirit and practical ability.

Key words: cellular and molecular basis, reform practices of experimental courses, “scenario-based” experimental class, innovative scientific research thinking