Abstract: Biochemistry is one of the most important basic courses in the field of life sciences but is difficult to learn due to too many knowledge points in this course. The development of information and network technology has brought new opportunities and challenges to the reform of higher education. The "Tsinghua education online (THEOL)" network teaching platform provides a new opportunity for the mixed teaching reform of this course. This paper discusses the author′s experience in the application of THEOL teaching platform during the teaching reform of biochemistry. It systematically describes the advantages of THEOL teaching platform in promoting the innovation of teaching concepts, ensuring the live update of teaching knowledge, improving students′ initiative and participation, tracking after-school learning, promoting the reform of curriculum assessment methods, and facilitating integration and utilization of the network resource. In practice, the blending learning can effectively promote college students to think and improve their ability to ask, analyze and solve problems. This study aims to provide a basis for the reform and research of biochemistry curriculum.

Key words: THEOL platform, biochemistry, blending learning