Abstract: Cadmium has strong biological toxicity. It could be absorbed by smoking, dietary and inhalation. Cadmium could lead to series damage to mammalian, including bone misshapen, kidney injury and cancer; it can also lead to abnormal lipid metabolism. In recent years, many researchers found that cadmium could lead to cardiovescular diseases in mammalians, such as heart attack, hypertension and so on，however, the mechanism is still unknown. The mechanism of this phenomenon could be the result of ROS(Reactive oxygen species) production, Na+/K+ ATPase activity inhibition and impaired VE-cadherin function. Here, we discussed the research progress in mechanisms of cadmium induced hypertension.

Key words: cadmium, cardiovescular diseases, VE-cadherin, ROS, Na+/K+ ATPase