生物学杂志

Journal of Biology ›› 2021, Vol. 38 ›› Issue (6): 99-.doi: 10.3969/j.issn.2095-1736.2021.06.099

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Research progress on African swine fever virus and its vaccines

  

  1. 1.Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, China;
     2. Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou University, Yangzhou 225009, China;
    3. Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou 225009, China;
      4. Joint International Research Laboratory of Agriculture and Agri-product Safety of the Ministry of Education,
    Yangzhou University, Yangzhou 225009, Chin
  • Online:2021-12-18 Published:2021-12-15

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Abstract: Taking African swine fever virus (ASFV) as the research object, pathogenic characteristics of ASFV including virus structure, infection and immune mechanism, transmission route, and pathogenicity were summarized. Meanwhile, the research status of African swine fever (ASF) vaccines was analyzed: inactivated vaccines cannot provide protection; subunit vaccines, nucleic acid vaccines and viral vector vaccines usually provide partial protection; live attenuated vaccines can provide homologous protection and are most potential for clinical application. On this basis, it was found that the complexity of ASFV and the uncertainty of immunobiological characteristics affect the progress of vaccine research. And the challenges in development of ASF vaccines faced by China were put forward to providing a new understanding and approach for vaccine development.

Key words: African swine fever, virus, infection, immunity, vaccine

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