Abstract: Photosynthetic biomanufacturing is a new mode of biomanufacturing technology. Taking microalgae as chassis，photosynthetic biomanufacturing technology could directly convert solar energy and carbon dioxide into biofuels and bio⁃based chemicals in a single process and single platform，simultaneously achieving the effects of carbon reduction and green production. Toward application of photosynthetic biomanufacturing technology in industrial process，development of high⁃efficiency microalgae chassis cells and photosynthetic cell factories with fast growth rates，high synthesis efficiency，and strong industrial properties，as well as adapted process technology and system，would be prerequisites. This article presented the progress on engineering "editable，controllableandapplicable" microalgae chassis cells and photosynthetic cell factories through application of synthetic biology tools and strategies，in order to scale up the photosynthetic biomanufacturing technology in industrial process.

Key words: microalgae, synthetic biotechnology, chassis cell, photosynthetic cell factory, photosynthetic biomanufacturing