Abstract:

Ribosomal protein S6 kinase A3 (RPS6KA3) has Serine/Threonine kinase activity that plays an important role in the body′s physiological processes. In order to study the nature and function of gene RPS6KA3, bioinformatics analysis of its gene sequence and the structure and properties of its encoded protein was analyzed by a series of bioinformatics analysis software in this paper. The results showed that the human RPS6KA3 gene encoded a polypeptide comprised of 740 amino acids residues, which was highly conserved in the evolutionary process and belonged to the PKc_like super family. It was an unstable and water-soluble protein with isoelectric point of 6.41 without signal peptide sequence and trans-membrane region detected in this protein. It was mainly located in the cytoplasm, and the main secondary structure elements were alpha helix structure with several phosphorylation sites. Interactive proteins with RPS6KA3 were mainly proteins associated with MAPK and mTOR signaling pathway and protein synthesis. Our results could provide important messages for further studing on the function of RPS6KA3 in the life process

Key words: RPS6KA3 gene, bioinformatics, signaling pathway