Abstract: As a model organism, fruit flies play an extremely important role in embryonic development, pathogenesis of diseases and regulation of gene expression. When the fruit flies are stimulated by stressors, the cells in the body respond to a series of stress responses to maintain homeostasis. JNK signaling pathway plays a key role in fruit flies stress reaction. In this paper, combining with the latest research progress of related protein interactions from the JNK signaling pathway and negative regulatory factors of regulation, the stress response caused by the JNK signaling pathway related function were summarized.

Key words: stress response, JNK signaling pathway, negative regulatory factor