生物学杂志

生物学杂志 ›› 2023, Vol. 40 ›› Issue (5): 94-.doi: 10.3969/j.issn.2095-1736.2023.05.094

• 综述与专论 • 上一篇    下一篇

基于MAPK主要信号通路探讨动物抗菌肽免疫调控机制研究进展

徐晨露， 夏　嫱   

  1. 遵义医科大学 珠海校区基础教学部， 珠海 519041
  • 出版日期:2023-10-18 发布日期:2023-10-17
  • 通讯作者: 夏嫱，博士，教授，研究方向为昆虫分子免疫学，E-mail:xiaqiang1973@126.com
  • 作者简介:徐晨露，硕士，研究方向为分子免疫学，E-mail:944377008@qq.com
  • 基金资助:
    国家自然科学基金项目（32060127）；贵州省科技计划项目（黔科合基础-ZK\[2021\]一般101）

Research progress on immune regulation mechanism of animal antimicrobial peptides based on MAPK main signaling pathway

XU Chenlu, XIA Qiang   

  1. Department of Basic Education, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, China
  • Online:2023-10-18 Published:2023-10-17

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摘要： 重点介绍近年来有关动物抗菌肽基于MAPK信号通路免疫调控机制方面的最新研究进展。概述JNK、P38 MAPK、ERK等3个MAPK亚通路及动物抗菌肽基于MAPK通路免疫调控机制的研究现状，阐明哺乳类、鸟类、爬行类、两栖类、鱼类、昆虫类及甲壳类动物抗菌肽通过磷酸化MAPK通路参与免疫反应的机制。通过对各类动物抗菌肽基于MAPK通路免疫调控机制的整理和总结，期待能够为全面深入研究抗菌肽作用机制及抗菌肽在医药领域作用靶点研究提供参考。

关键词: 抗菌肽, 丝裂原活化蛋白激酶, 信号通路, 免疫调控, 机制

Abstract: The latest research progress of animal antibacterial peptides in immunoregulation mechanisms was mainly introduced based on the MAPK signaling pathway in recent years. The research status of three MAPK subpathways, JNK, P38 MAPK and ERK, and the immunological regulation effects of animal antimicrobial peptides based on the MAPK pathway were summarized. The mechanisms by which antimicrobial peptides from mammals, birds, reptiles, amphibians, fish, insects and crustaceans through phosphorylation of MAPK pathway to involve in immune responses were also elucidated. The immunomodulatory mechanisms of various animal antimicrobial peptides based on the MAPK pathway were arranged and summarized, hoping to provide a literature reference for the comprehensive and in-depth research of the mechanism of antimicrobial peptides and the acting targets of antimicrobial peptides in the field of medicine.

Key words: antimicrobial peptide, mitogen-activated protein kinase, signaling pathway, immune regulation, mechanism

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