关键词: 综述NAD⁺代谢机制及其对衰老相关疾病的影响研究进展。重点从NAD⁺的生物合成途径、消耗途径及其调控机制等方面阐述NAD⁺参与的信号通路和细胞过程, 以及它在健康与疾病中的作用, 并且以NAD⁺代谢网络中前体物质和关键酶的作用机理为依据, 探讨NAD⁺代谢调控在衰老相关疾病中的潜在治疗方法, 为理解NAD⁺水平下降和衰老相关疾病之间复杂的因果关系提供新的视角；同时从NAD⁺及其前体的分布和运输、有毒代谢物的产生和修复、NAD⁺代谢动态的监测和测量等方面阐述NAD⁺研究发展过程中存在的瓶颈。最后展望以NAD⁺为靶点进行疾病治疗和药物开发的广阔前景。

Abstract: In this work, we reviewed the research progress of NAD⁺metabolism mechanism and its effect on aging-related diseases, focusing on the signaling pathways and cellular processes involved in NAD+, as well as its role in health and diseases from the aspects of NAD⁺biosynthesis pathway, consumption pathway and its regulatory mechanism. Based on the mechanism of action of precursors and key enzymes in the NAD⁺metabolic network, the potential therapeutic approaches of NAD⁺metabolism regulation on aging-related diseases were discussed, providing new perspectives for understanding the complex causal relationship between NAD+levels decline and aging-related diseases. The issues to be solved in the process of NAD⁺research and development were summarized from the aspects of the distribution and transportation of NAD+and its precursors, the production and repair of toxic metabolites, and the monitoring and measurement of NAD⁺metabolic dynamics, and finally, the broad prospects for disease treatment and drug development with NAD⁺as the target were prospective.