关键词: 天然产物, 毛兰素, 抗肿瘤, 分子机制, 信号通路

Abstract: Natural products are an important source of anti-tumor drugs. Based on the sorting and analysis of current studies at home and abroad, this paper summarized the anti-tumor effect and anti-tumor molecular mechanism of bibenzyl small molecule erianin in medicinal plants Dendrobium candidum and Dendrobium chrysotoxum. Firstly, the medicinal history and pharmacological activities of Dendrobium natural products, as well as the various pharmacological effects of erianin, especially its antitumor effects were introduced and explored. Combined with a number of in vitro and in vivo studies, the inhibitory effects of erianin on tumor proliferation of many cancer cell lines were introduced. By combing and analyzing the available research, this paper analyzed the role of erianin in tumor regulation by inducing cancer cell apoptosis, autophagy, blocking cancer cell cycle, inhibiting cancer cell migration and invasion, inhibiting tumor angiogenesis and other molecular mechanisms, and summarized several erianin related signal pathways and factors such as JNK, PI3K / Akt, ERK. Finally, in view of research status of erianin. The prospect of erianin in patent medicine research and clinical application was prospected.

Key words: natural products, erianin, anti-tumor, molecular mechanism, signaling pathway