生物学杂志

生物学杂志 ›› 2021, Vol. 38 ›› Issue (1): 93-.doi: 10.3969/j.issn.2095-1736.2021.01.093

• 综述与专论 • 上一篇    下一篇

FAM83蛋白调控肿瘤发生机制及临床应用研究进展

  

  1. 1. 湖北工业大学 生物工程与食品学院， 武汉 430068；  2. 湖北工业大学 国家外专局/教育部细胞调控与分子药物学科创新“111”引智基地， 武汉 430068
  • 出版日期:2021-02-18 发布日期:2021-02-22
  • 通讯作者: 周策凡，博士，副教授，研究方向为细胞调控与分子药物，E-mail：cefan@whu.edu.cn;唐景峰，博士，教授，博导，研究方向为细胞调控与分子药物，E-mail：tangjingfeng@hbut.edu.cn
  • 作者简介:刘南茜，硕士，研究方向为细胞调控与分子药物，E-mail：nanxiliu@yeah.net
  • 基金资助:
    国家自然科学基金项目 (31871420, 31871176, 31701228)

Research progress on the mechanism and clinical application of FAM83 protein in regulating tumorigenesis#br#

  1. 1. School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, China;2.National "111" Center for Cellular Regulation and Molecular Pharmaceutics,Hubei University of Technology, Wuhan 430068, China
  • Online:2021-02-18 Published:2021-02-22

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摘要： 根据FAM83A蛋白家族的结构特点和生物学特性，综述肿瘤细胞中FAM83异常表达及功能活性调控的因素（非编码微小RNA和蛋白质修饰作用）和它们促成肿瘤发生的潜在机制（MAPK，Wnt和TGF-β信号通路）及在肿瘤诊断与临床治疗方面的应用（分子marker诊断和肿瘤耐药）。分析FAM83基因在多种人类恶性肿瘤细胞中过表达，并且与肿瘤细胞的增殖、迁移、侵袭、转化和耐药等过程相关。探讨FAM83蛋白在肿瘤治疗中的前景和挑战，未来将探究每个FAM83蛋白的独特功能，为今后以FAM83蛋白家族为癌症治疗的新靶点提供理论依据。

关键词: FAM83, 异常表达, 信号通路, 肿瘤细胞, 治疗靶点

Abstract: Based on the structural and biological characteristics of the FAM83 protein family, this paper reviewed the regulatory factors, such as MicroRNA and protein posttranslational modification, for FAM83 proteins dysregulated expression and the functional activity in tumor cells and their potential mechanisms for tumorigenicity (MAPK, Wnt and TGF-β signaling pathways), as well as their application in cancer diagnosis and clinical treatment (molecular marker diagnosis and tumor drug resistance). The FAM83 genes were found to be up-regulated in various tumor cells and associated with cellular biological processes such as proliferation, migration, invasion, transformation and drug resistance. Finally, the prospects and challenges of the FAM83 protein in tumor therapy were discussed. In the future, the unique functions of each FAM83 protein will be explored to provide theoretical basis for future novel targets of the FAM83 protein family for cancer treatment.

Key words: FAM83, abnormal expression, signal pathway, tumor cells, therapeutic target

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