生物学杂志

生物学杂志

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Rho/ROCK信号通路功能及其活性调节

  

  1. 1. 抗衰老中草药安徽省工程技术研究中心 阜阳 236041; 2. 安徽大学生命科学学院 合肥 230601
  • 出版日期:2015-12-18 发布日期:2015-12-18
  • 通讯作者: 屈长青，汉族，教授，博士；研究方向：脂肪干细胞分化调控，E-mail: qucq518@ 163.com。
  • 作者简介:曹美霞，汉族，硕士研究生; 研究方向: 脂肪干细胞分化调控，E-mail:caomeixia0927@ 163.com;
  • 基金资助:
    国家自然科学基金(项目批准号：31172182、31201788)

Rho/ROCK signaling pathway and its active regulation mode

  1. 1. Engineering Technology Research Center of Anti-aging Chinese Herbal Medicine， Fuyang 236041; 2. College of Life Sciences，Anhui University， Hefei 230601， China
  • Online:2015-12-18 Published:2015-12-18

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摘要： Rho-ROCK信号在细胞分化，细胞周期进展，增殖和凋亡中发挥着重要的作用。机体通过调节Rho-ROCK信号及其相关性因子可以诱导间充质干细胞(mesenchymal stem cells ，MSCs)分化脂肪细胞，成骨细胞，成软骨细胞等。不同阶段ROCK信号通路的失调与心血管、代谢、神经退行性疾病、以及癌症的发生有关。本文主要阐述Rho-ROCK信号通路功能及调节Rho-ROCK活性的各种模式，为研究与之相关疾病提供思路。

关键词: Rho, Rho激酶, ROCK, 分化

Abstract: Rho-ROCK signal plays an important role in cell differentiation, cycle progression, proliferation and apoptosis. By regulating the Rho-ROCK signal and correlation factors the body can induce mesenchymal stem cells (mesenchymal stem cells, MSCs) to differentiate into adipocytes, osteoblasts, chondroblasts. At different stage dysregulation of the Rho-ROCK signaling pathway is linked to cardiovascular, metabolism, neurodegenerative diseases,as well as cancer. The review is mainly explained Rho-ROCK signal pathway and various modes of regulation of Rho-ROCK activity,thereby in order to study related diseases provide some new thoughts.

Key words: Rho, Rho kinase, ROCK, differentiation