生物学杂志 ›› 2020, Vol. 37 ›› Issue (4): 90-.doi: 10.3969/j.issn.2095-1736.2020.04.090

• 综述与专论 • 上一篇    下一篇

神经酰胺从头合成途径关键代谢酶的研究进展

  

  1. 天津大学 生命科学学院, 天津 300072
  • 出版日期:2020-08-18 发布日期:2020-08-10
  • 通讯作者: 陈成,博士,副教授,主要研究方向为结构与分子生物学,E-mail:chengchen@tju.edu.cn
  • 作者简介:李玉慧,硕士,主要研究方向为罕见病致病因子的结构及功能, E-mail:yuhuili@tju.edu.cn
  • 基金资助:
    国家重点基础研究发展计划(973计划)(2015CB859800)

Research progress on key metabolic enzymes in de novo synthesis pathway of ceramide

  1. School of Life Sciences, Tianjin University, Tianjin 300072, China
  • Online:2020-08-18 Published:2020-08-10

摘要: 神经酰胺是调控细胞分化、增殖、凋亡,调节机体衰老与肿瘤免疫等重大生命活动的重要活性脂质,同时也是糖鞘脂等一系列重要生理鞘脂合成的通用前体。作为鞘脂代谢的中心,神经酰胺在机体内的合成与降解受到严格调控,其合成包括从头合成途径、鞘磷脂酶途径及补救途径。尽管从头合成途径对于神经酰胺在机体内的合成量贡献仅为5%~10%,但近年来对该条途径中关键代谢酶的研究却表明了它们与诸多疾病密切相关,这也说明了该途径在机体生命活动中的复杂性与重要性。旨在系统性地综述神经酰胺从头合成途径关键代谢酶的研究进展,为深入了解该途径以及关键代谢酶的功能提供理论参考,同时也为今后针对该途径的个性化药物开发奠定基础。

关键词: 神经酰胺, 从头合成途径, 合成酶, 疾病相关性, 三维结构

Abstract: Ceramide is an important active lipid that regulates cell differentiation, proliferation, apoptosis, aging, tumor immunity and other vital life activities, and it is also a universal precursor for a series of important physiological sphingolipids such as glycosphingolipids. As the center of sphingolipid metabolism, the syntheses and degradations of ceramide in the body are strictly regulated. Its syntheses include de novo synthesis pathway, sphingomyelinase pathway and remedy pathway. Although de novo synthesis pathway contributes only 5%-10% to the synthesis of ceramide in the body, recent studies on key metabolic enzymes in this pathway have shown that they are closely related to many diseases, which also illustrates the complexity and importance of this pathway in the life of the organism. The purpose of this article is to systematically review the research progress of key metabolic enzymes in de novo synthesis, in order to provide a theoretical reference for further understanding of this pathway and the functions of key metabolic enzymes, and also lay an foundation for the development of personalized medicine for this pathway in the future.

Key words: ceramide, de novo synthesis, synthetase, disease correlation, three-dimensional structure

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