关键词: 稳态磁场, 动态磁场, 肿瘤侵袭, 转移, 磁性纳米颗粒

Abstract: There are a number of cellular and animal studies about static magnetic fields and low-frequency rotating magnetic fields based on permanent magnets have shown inhibitory effects on tumor growth. However, tumor metastasis is one of the major reasons for cancer patient lethality, which is a hotspot for medical research. Currently, there are some studies showing that magnetic fields themselves can affect the invasion and migration of tumor cells, as well as cancer metastasis. People have also taken advantage of nanotechnology by combining magnetic fields with different parameters and nanomaterials for tumor targeting and thermomagnetic effects, which have shown great progression in tumor metastasis inhibition and tumor cell enrichment. This review summarized, analyzed and compared the relevant data on the invasion and migration of tumor cells, the metastasis of tumor cells in static magnetic field and the dynamic magnetic field, as well as the magnetic field combined with nanomaterials, including magnetic field parameters and treatment, cell type and the resulting intracellular changes. This helped people not only understand the effects of the magnetic field exposed in daily life on the organism, but also optimize the magnetic field parameters in the future, so that the magnetic fields can be applied to tumor-assisted treatment.

Key words: static magnetic fields, dynamic magnetic fields, tumor invasion, metastasis, magnetic nanoparticles