生物学杂志

生物学杂志

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PSD-95与老化相关学习记忆能力下降关系研究进展

  

  1. 1.浙江大学 医学院 基础医学系， 杭州 310058; 2. 浙江大学城市学院 医学院 临床医学系， 杭州 310015
  • 出版日期:2019-04-18 发布日期:2019-04-18
  • 通讯作者: 张雄，博士，副教授，研究方向为神经系统功能研究，E-mail：xiongzhang@zju.edu.cn
  • 作者简介:林江涛，硕士研究生，专业方向为认知能力与脑老化研究，E-mail：821719339@qq.com
  • 基金资助:
    浙江省自然科学基金（LY15H250001）

The recent researches in the relationship between PSD-95 and age related impairments in learning and memory

  1. 1. Department of Basic Medicine, College of Medicine, Zhejiang University, Hangzhou 310058; 2. Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China
  • Online:2019-04-18 Published:2019-04-18

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摘要： 学习记忆能力下降是老年人群脑老化的主要特征之一，这部分归因于突触结构和功能的改变而非神经元的死亡。突触后致密蛋白95（PSD-95）是突触后结构中的一种支架蛋白，其表达对于维持突触结构及突触可塑性十分重要。最近的研究发现PSD-95与脑老化密切相关，对PSD-95与脑老化的关系作一综述，重点关注PSD-95与脑老化相关学习记忆能力下降的关系，以期为脑老化机制的深入研究及相关疾病的防治提供参考。

关键词: 脑老化, 学习记忆, 突触, 突触后致密蛋白95

Abstract: Brain aging is associated with impairments in learning and memory, which can be explained partly by alterations in synaptic structure and function rather than neuronal loss. Postsynaptic density protein 95 (PSD-95) is a major scaffolding protein in postsynaptic density and is important for maintaining the synaptic structure and plasticity. PSD-95 is considered to be associated with brain aging in recent studies. Thus, we reviewed the relationship of PSD-95 and brain aging, mainly focusing on impairments in learning and memory, hoping to provide a new sight for further researches in the mechanisms of brain aging and in preventing the related diseases.

Key words: brain aging, learning and memory, synapse, postsynaptic density protein 95

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