生物学杂志

生物学杂志 ›› 2019, Vol. 36 ›› Issue (5): 85-.doi: 10.3969/j.issn.2095-1736.2019.05.085

• 综述与专论 • 上一篇    下一篇

uPAR在肿瘤诊断与治疗中的研究进展

  

  1. 1.安徽大学 物质科学与信息技术研究院， 合肥 230601; 2.安徽天祥粮油食品有限公司， 阜阳 236300
  • 出版日期:2019-10-18 发布日期:2019-10-11
  • 通讯作者: 徐昌志，博士，讲师，研究方向为细胞工程，E-mail: changzhixu007@163.com;张部昌，博士，教授，研究方向为生物工程和食品工程，E-mail: zhbc@ahu.edu.cn
  • 作者简介:韩倩倩，硕士研究生，研究方向为细胞工程，E-mail:1792518268@qq.com
  • 基金资助:
    国家自然科学基金（31600749）

Research progress of uPAR in diagnosis and therapy of tumors

  1. 1. Institute of Physical Science and Information Technology, Anhui University, Hefei 230601; 2. Anhui Tianxiang Grain and Oil Food Company, Fuyang 236300, China
  • Online:2019-10-18 Published:2019-10-11

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摘要： 尿激酶型纤溶酶原激活物受体(urokinase-type plasminogen activator receptor，uPAR)是一种糖基磷脂酰肌醇锚定蛋白，除调节蛋白质水解外，还可与跨膜受体协同激活细胞内多条信号通路，促进细胞增殖、侵袭及迁移等。uPAR在多种恶性肿瘤中特异性高表达，成为肿瘤诊断和治疗的潜在靶点。目前，肿瘤诊断的成像技术主要有X射线、计算机断层扫描技术、核磁共振以及正电子发射断层扫描（positron emission tomography，PET）等，其中PET因其超高灵敏度和特异性而受到广泛关注。大量研究表明，基于靶向uPAR的小分子和抗体的PET成像能够实现肿瘤细胞的定位及定量检测。同时在肿瘤治疗方面，通过抑制uPA与uPAR相互作用及uPAR蛋白表达等方法能明显抑制结肠癌、乳腺癌、卵巢癌等癌细胞的增殖、侵袭及迁移等。主要综述了基于靶向uPAR的小分子和抗体的PET成像在肿瘤诊断中的作用，以及uPAR在肿瘤靶向治疗中的研究进展。

关键词: font-size:medium, ">uPAR；PET成像；诊断；肿瘤治疗

Abstract: The urokinase-type plasminogen activator receptor (uPAR) is a glysocylphosphatidylinositol (GPI) anchor protein, which regulates proteolysis and cooperate with transmembrane receptors to activate a series of signaling pathways in cells, promoting cell proliferation, invasion and migration. Meanwhile, uPAR was overexpressed in a panel of malignancies, which has become a potential target for tumor diagnosis and treatment. At present, imaging techniques for tumor diagnosis mainly include X-ray, computed tomography, nuclear magnetic resonance and positron emission tomography(PET), among which PET has received extensive attention due to its ultra-high sensitivity and specificity. Accumulating reports have shown that PET imaging with small molecules and antibody targeting uPAR could achieve localization and quantitative detection of tumor cells. At the same time, the proliferation, invasion and migration of colon cancer, breast cancer and ovarian cancer could be significantly inhibited by blocking the interaction between uPA and uPAR or repressing the expression of uPAR in cancer therapy. In this review, we summarized the role of PET imaging with small molecules and antibody targeting uPAR for tumor diagnosis and the research progress of uPAR for tumor-targeted therapy. 

Key words: font-size:medium, ">uPAR； PET imaging； diagnosis； tumor therapy

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