Abstract: IFNLR1 encoded protein belongs to the type Ⅱ cytokine receptor family. IFNλ identifies and combines with the dimer receptor complex formed by IFNLR1 chain and IL-10RB chain, and then activates the classic Jak-STAT signaling pathway. Molecular structure of IFNLR1 was studied and the three-dimensional structure was depicted. The expression pattern of IFNLR1 is of tissue specificity, while type Ⅰ interferon receptors are ubiquitously expressed. Research on gene function of IFNLR1 is mainly based on house mouse model. So far, it is known that IFNLR1 is involved in biological activities, including anti-virus, anti-tumor and immunomodulation. The related research is still further explored.

Key words: IFNLR1, IFNλs, Jak-STAT signaling pathway