Abstract: Cancer stem cells (CSCs) can self-renew and differentiate into different germline cancer cells, while the specific microenvironment of CSCs is essential for the division of CSCs. The spread of cancer and the tumor recurrence are highly related to the microenvironment of CSCs, and the construction of efficient tumor targeting therapy relies on the adequate understanding about this regulation mechanisms. Therefore, this review mainly focuses on the latest findings in the field of CSCs microenvironment, especially in the research of colorectal cancer, breast cancer, leukemia and inoculated tumor.

Key words: cancer stem cells (CSCs), microenvironment, regulation mechanism