Abstract: Natural selection plays an important role in changing the gene frequency of a population. The change of population genetic structure caused by the selection is an adaptive change. Therefore, natural selection is considered to be the main factor of species adaptive evolution. Considering the importance of the concept in explaining biological evolution, it has received much attention in the teaching of genetics. In order to better display the effect of natural selection on genetic equilibrium, Excel 2003 is used to simulate the selection process, and it is expected to understand the selection process more vividly and profoundly.

Key words: genetic equilibrium, natural selection, excel, simulation