Abstract: GDP dissociation inhibitor (GDI) is common in plants, mammals and other species, it is one of the key regulatory factors of guanosine triphosphatase (GTPases) activity, and plays a crucial role in the regulation of GTPases activity. GTPases can bind and hydrolyze GTP, and GDI can participate in regulating the conversion of small G proteins between the GTP-bound activated state and the GDP-bound deactivated state, controlling numerous signal transduction pathways. In this paper, we summarize the research progress of the role of GDI in different organisms such as mammals and plants. In the process of disease occurrence, GDI is mainly involved in the regulation of human cancer, vascular permeability and other related diseases. In addition, GDI also plays an important role in insulin secretion, male infertility and the course of preeclampsia. In plants, GDI is involved in regulating the polar growth of pollen tube or root hair, affecting plant morphogenesis, and also plays an important role in plant stress resistance. This paper provides a theoretical basis for the study of the biological function of GDI.

Key words: GDI, tumor development, vascular permeability, plant polarity, plant morphogenesis, plant stress resistance