Abstract: In recent years, in the online plus offline blending teaching of cell biology, it was found that negative performances of resistance and/or improper use, which might affect teaching quality. Combined the traditional teaching paradigm, the achievements of predecessors and our teaching practice, this paper takes the teaching content of "cell death" as an example to summarize the ways to improve the quality of online and offline blending teaching. Firstly, the concept of blending teaching shall be rationally understood and accepted. Secondly, guided under the traditional teaching paradigm, learning and teaching performance shall be analyzed, the training plans shall be formulated, and teaching content shall be reasonably reconstructed. Thirdly, the teaching content shall be refined, and the teaching mode shall be designed and optimized. And finally, sustainable development of the process and multiple assessment system can effectively promote a student-teacher interaction, inspire learning interest, and cultivate entrepreneurial and innovative mindset and abilities.

Key words: cell biology, cell death, online plus offline blending teaching, massive online open course, teaching design