生物学杂志

Journal of Biology ›› 2023, Vol. 40 ›› Issue (2): 95-.doi: 10.3969/j.issn.2095-1736.2023.02.095

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Research progress of UDP-sugar biosynthesis

CHEN Guihang1, LI Chun1,2, FENG Xudong1   

  1. 1. Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information
    Technology, Institute of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of
    Technology, Beijing 100081, China; 2. Key Lab for Industrial Biocatalysis, Ministry of Education, Department of
    Chemical Engineering, Tsinghua University, Beijing 100084, China
  • Online:2023-04-18 Published:2023-04-18

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Abstract: Uridine diphosphate(UDP)-sugar is an important type of sugar donors for glycosylation modification. The in vivo synthesis of UDP-sugar was summarized from three aspects: synthase pathway, phosphorylase pathway and kinase pathway. Due to the lack of key enzymes, only UDP-glucose (UDP-Glc) could be quickly obtained from the above three pathways. At the same time, with UDP-glucose as the starting material and UDP-glucuronic acid (UDP GlcA) as the intermediate, the rapid interconversions between UDP-sugars could be realized by specific functional enzymes. The latest progress in UDP-sugar synthesis catalyzed by specific functional enzymes was reviewed, and the important roles of dehydrogenase, decarboxylase, isomerase and reductase in UDP-sugar interconversions were discussed. The existing problems of UDP-sugar synthesis were analyzed and the future research direction of UDP-sugar synthesis was prospected, aiming at providing new ideas for tapping the potential of UDP-sugar donors and realizing glycosylation modification with efficiency and low cost.

Key words: UDP-sugar, biosynthesis, dehydrogenase, decarboxylase, isomerase, reductase

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