生物学杂志

Journal of Biology ›› 2023, Vol. 40 ›› Issue (2): 91-.doi: 10.3969/j.issn.2095-1736.2023.02.091

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Research progress on mechanism of African swine fever virus regulating host immune response

YUAN Li1,2,3,4, XIONG Dan1,2,3,4, KANG Xilong1,2,3,4, PAN Zhiming1,2,3,4, JIAO Xin’an1,2,3,4   

  1. 1.Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, China; 2.Jiangsu Co-innovation
    Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China;
    3.Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and
    Quality of the Ministry of Agriculture and Rural Affairs of China, Yangzhou 225009, China; 4.Joint International
    Research Laboratory of Agriculture and Agri-product Safety of the Ministry of Education, Yangzhou 225009, China
  • Online:2023-04-18 Published:2023-04-18

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Abstract: African swine fever virus (ASFV) encodes a variety of immune escape proteins to antagonize the host immune response, resulting in the persistent infection of the virus in the host. The main difficulty in the development of African swine fever (ASF) vaccine is that little is known about the virulence related genes, pathogenicity and immune regulation mechanism of ASFV. This paper summarized the immune regulation mechanism of African swine fever virus (ASFV) after invading the host. It discussed the specific function of ASFV immune-regulation proteins from the perspective of innate immunity and acquired immunity: regulating inflammation, interferon production, antigen presentation and cellular immunity, and explored potential new vaccine candidates of ASFV: recombinant NH/P68 attenuated strain, new fusion protein ZPMT, gene deletion strain ASFV-ΔECM3, etc, so as to provide reference for the study of ASFV pathogenesis and the development of new vaccines.

Key words: African swine fever virus, immune regulation, immune evasion protein, molecular mechanism, vaccine development

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