生物学杂志

Journal of Biology ›› 2022, Vol. 39 ›› Issue (4): 12-.doi: 10.3969/j.issn.2095-1736.2022.04.012

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Effects of extinction of morphine addiction and naloxone on the EEG power spectrum in the prefrontal cortex

  

  1. 1. MOE Engineering Research Center of Sustainable Development and Utilization of Bioenergy, Kunming &
    Key Laboratory of Yunnan for Biomass Energy and Biotechnology of Environment, School of Life Sciences,
    Kunming 650500, China; 2. School of Physical Education, Yunnan Normal University, Kunming 650500, China;
    3. Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology, School of Ecology and
    Environmental Science, Yunnan University, Kunming 650500, China; 4. NHC Key Laboratory of Drug Addiction
    Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
  • Online:2022-08-18 Published:2022-08-15

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Abstract: To investigate the effects of training extinction (TE) and natural extinction (NE) on the EEG power spectrum of the prefrontal cortex (PFC) of mice with morphine (MOP) addiction and the regulation of naloxone (NLX), KM mice were given increasing doses of MOP (10, 15, 20, 25, 30 mg/kg) or saline (SAL) for 10 d, and the conditioned position preference (CPP) model was established. After 5 d extinction, the PFC-EEG signal was recorded with NLX (5 mg/kg) treatment. Results showed that, after 5 d TE treatment, the CPP score in the MOP-TE group decreased to the level as its baseline or the SAL group, with the total EEG power decreased (P<0.05). The CPP score was still higher in MOP-NE group, with the total power similar to that in SAL group (P>0.05). After NLX injection, the power of MOP-TE group increased rapidly, and the power of θ, α, β and γ1bands also showed similar performance. The results suggested that the PFC-EEG power spectrum would be an important electrophysiological index on involvement of the PFC in extinction of opioid drug addiction, and in which, the NLX would have a certain improvement effect.

Key words: morphine addiction, naloxone, conditioned place preference, prefrontal cortex, EEG power spectrum, KM mine

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