Abstract: Alternative splicing is a key mechanism for regulating gene expression in mammals. Recent evidence demonstrates that approximately 95% of human genes with multiple exons undergo alternative splicing, with the development of high-throughput sequencing technology and bioinformatics technology, the study of alternative splicing gradually progressed from single gene to group level, the high-throughput data emerging, the integration of data between the various groups, making a systematic, comprehensive study of alternative splicing is possible. The abnormal of alternative splicing may lead to cancer, and glioma is one of the malignant tumors of the brain. The lethality rate is very high and the survival rate is very low. In this paper, we reviewed the progress of the study on the mechanism of alternative splicing of glioma in recent years, and made a preliminary prospect of the clinical treatment of splicing level.

Key words: alternative splicing, glioma, multi-omics data