Abstract: Infectious diseases are a kind of transmitted diseases caused by pathogenic microorganisms, which can affect human and animal health and even produce great social economic burden. Compared with vaccination, antiviral drugs and other control methods, antibody has gradually become an important strategy for the treatment of infectious diseases because of its small side effects and strong timeliness. Neutralizing antibody is a kind of antibody that can specifically bind to the surface antigen of infectious particles, thereby blocking its interaction with the host cells and preventing cells from being invaded. A variety of neutralizing antibodies against viral infection have been developed. In this paper, the research progress of four typical virus therapeutic antibodies for SARS-CoV-2, Ebola, HIV and RSV was reviewed, including representative antibodies targeting the SARS-CoV-2 S protein, ebola GP protein, HIV gp160 protein and RSV F protein. The selection of neutralizing antibody target and its future development and application were discussed.

Key words: neutralizing antibody, viral infectious diseases, treatment, SARS-CoV-2, Ebola virus