Journal of Biology ›› 2024, Vol. 41 ›› Issue (6): 96-.doi: 10.3969/j.issn.2095-1736.2024.06.096

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Research progress on the effects of BDNF on central nervous system diseases #br# #br#

SONG Xueqing1, SUN Yalun1, ZHOU Lifang2, WANG Songhua1, MENG Wei1   

  1. 1. 江西科技师范大学 有机功能分子研究所, 南昌 330013;
    2. 江西科技师范大学 生命科学学院, 南昌 330013
  • Online:2024-12-18 Published:2024-12-16

Abstract: This article introduced the important role of brain-derived neurotrophic factor (BDNF) in central nervous system (CNS) function and related diseases, including promoting neuronal growth and survival, enhancing synaptic plasticity, participating in the regulation of neurotransmitters, promoting myelination, and neuroprotective effects, which suggested that BDNF plays an important role in the improvement and treatment of CNS diseases. By summarizing the animal experiments and preclinical studies related to BDNF, the research progress on the effects of BDNF on CNS diseases, such as spinal cord injury, traumatic brain injury, ischemic brain injury, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, epilepsy and depression, and the molecular mechanism of BDNF in CNS diseases were summarized, which provided ideas for exploring the effects of BDNF in the treatment of related CNS diseases. In the future, the pharmacokinetics mechanism of BDNF can be explored in experimental animals, and different delivery methods of BDNF and its derivatives can be developed to treat CNS related diseases.

Key words: brain-derived neurotrophic factor, CNS injury, neurodegenerative diseases, epilepsy, depression

CLC Number: