Abstract: The microenvironment composed of cells adjacent to intestinal stem cells （ISCs） is key to the function of ISCs by providing a variety of essential signaling factors that regulate important signaling pathways for proliferation and differentiation in ISCs. Paneth cells are important providers of ISCs microenvironmental signaling molecules, and they can provide Wnt, Notch, EGF, mTORC1 and other related signaling factors for ISCs to maintain the balance of proliferation and differentiation. The signaling factors secreted by the Paneth cell are summarized here, to provide some ideas for the study of interaction between Paneth cells and ISCs, and the treatment of some intestinal epithelial homeostasis disorders.

Key words: Paneth cells, microenvironment, intestinal stem cells, signaling factors, intestinal epithelial homeostasis