Abstract: Consuming large quantities of alcohol over a short time can lead to acute alcoholism, which usually causes gastrorrhagia and cardiovascular disease. These diseases have become the most common clinical symptoms. Recently, synthetic drugs used to treat acute alcoholism have side effects on the body. Therefore, it is urgent to discover some natural active substances that can replace synthetic drugs. The goal of this article is to study the protective effect of polysaccharide from spirulina on acute alcoholism. Thirty mice were randomly divided into control (blank), model (alcohol injury), positive control, treatments (low PSP and high PSP dose). The low PSP and high PSP dose treatments were continuously taking polysaccharide from spirulina for 21 days (1 time/d). The positive control was given a continuous bifendate pills for 21 days (1 time/d). The blank control and alcohol injury were given solvent (water) for 21 days (1 time/d). After 22 days, except for the control group, others were given 50% alcohol (12 mL/kg) by means of intragastric. All groups mice were killed 12 hours later, and then the hearts, kidneys, thymus and livers were dissected from mice. The tissues were ground and then the supernatants were collected. The activities of catalase (CAT), glutathione (GSH), malondialdehyde (MDA), alanine aminotransferase (ALT) and aspartic aminotransferase (AST) were analyzed. The results showed that compared with the model group, the contents of CAT and GSH in treatments increased significantly and the content of MDA decreased dramatically. In liver tissue, the contents of ALT and AST decreased distinctly and returned to the level of positive control group. The above results would provide a scientific basis for the treatment of oxidative damage in the kidney, heart, liver and thymus caused by acute alcoholism.

Key words: polysaccharide Spirulina platensis (PSP), acute alcoholism, organs, oxidative injury, protective effects